DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006538970.1	Gene:	Epb41 / 269587	MGIID:	95401	Length:	1025	Species:	Mus musculus

Alignment Length:	921	Identity:	248/921 - (26%)
Similarity:	357/921 - (38%)	Gaps:	232/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWL 113
            |:.|.....:.|:|.|||:|.....:.|.|.|..|.::|...|:::|:|||||...|:...|.||
Mouse   202 QKPVRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLALWDSATSKTWL 266

  Fly   114 DPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELC 178
            |..|.|||||: |.|:.|...||||..:|..|.|::|||...|||:||::.|||.|.......|.
Mouse   267 DSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLG 330

  Fly   179 ALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLD 243
            :..:||||||||.:.|....||:|:..|.||::||..:::.:|:.|.:|||||:..||..||.|.
Mouse   331 SYTIQSELGDYDPELHGMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLS 395

  Fly   244 MYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGR 308
            |||||:|.....:|.:..||:..:|:||::...:|..|.|||:.|:.:|:....:.:     ...
Mouse   396 MYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI-----RPG 455

  Fly   309 EQEH---TFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQT 370
            ||||   |..|:|.:.:|.|.|||..|||||||||.:....|.::  |..:||:|||||||:.||
Mouse   456 EQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGSKFRYSGRTQAQT 518

  Fly   371 TQQSRA--RRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSP 433
            .|.|..  |....|||..|:|                        ||.:...||||.:...|..|
Mouse   519 RQASALIDRPAPHFERTASKR------------------------ASRSLDGAAAAESTDRSPRP 559

  Fly   434 APATPLVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQN----SAIIEPDAACSG 494
            ..|..:..||| |..|...               |..||..:|....:.    :...||:...:.
Mouse   560 TSAPAIAQSQV-TEGPGAP---------------IKKTPKEAVKVEEKRGEEPAEPAEPEPTEAW 608

  Fly   495 SISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDE 559
            .:..:........|.|..:.|.....||....:.....:..|..:         |..::....::
Mouse   609 KVEKTHTEVTVPTSNGDQTQKLAGKGEDLIRMRKKKRERLDGENI---------YIRHSNLMLED 664

  Fly   560 TNPFRNATSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDANSI 624
            .:..:.....||     ||||               ||.......|.:|.||
Mouse   665 LDKSQEEIKKHH-----ASIS---------------ELKKNFMESVPEPRPS------------- 696

  Fly   625 RVTINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNA 689
                          |..||||.     ::..:..|:|                   .::..|...
Mouse   697 --------------EWDKRLST-----HSPFRTLNIN-------------------GQVPTGDGV 723

  Fly   690 KLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLN--------------ATYIS--------- 731
            |.|:  .:|:.....                ||:|:|              :||.:
Mouse   724 KKTS--ILPSGRKVG----------------GPESVNGIRTEEVATVTKGPSTYPASEWECPKQS 770

  Fly   732 -VGGDKLTLSIPEQKPSTGSSSSSSTSSTATTTTNGNGPYSNATFV---------------SGFS 780
             |....|..:.|....|.||.|.|..|..|.....|...|.:|..:               |.||
Mouse   771 VVPSQSLMTTPPASPQSFGSGSLSINSKEAEEKEQGAAGYLDAEEMPTGPSGECLGVEEQASAFS 835

  Fly   781 APLTPPS----------------SLPANLNNTGSGC-------NTTLTSVTTISTP--SSPTATV 820
            .|:||.|                ...|....|.||.       |...|.:.:...|  .:.|.|:
Mouse   836 FPVTPASCQLQLGGEKADSSEELGAAAETLETQSGSFLDSPVGNQFPTLIRSFQPPLVKTQTVTI 900

  Fly   821 STTASESVAPALSNASAAEILINEIFINNIINNNASGSITAETAAKPAGSSTPSAGTLLFSTLSE 885
            |.||         ||..:||...::    .|.:..:.:||.|.|.....:.....|.||.:....
Mouse   901 SDTA---------NAVKSEIPTKDV----PIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTIT 952

  Fly   886 QERLESQKTNQ 896
            .|...|..|.|
Mouse   953 SETTSSTTTTQ 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	86/189 (46%)
		FERM_N	62..124	CDD:286467	27/61 (44%)
		FERM_M	143..250	CDD:278785	49/106 (46%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/95 (37%)
		FA	352..392	CDD:285894	20/41 (49%)
		PHA03255	771..>924	CDD:165513	36/166 (22%)
Epb41	XP_006538970.1	B41	212..402	CDD:214604	86/190 (45%)
		FERM_C_4_1_family	397..490	CDD:270005	37/97 (38%)
		FA	500..542	CDD:370090	21/67 (31%)
		SAB	662..709	CDD:367916	17/98 (17%)
		4_1_CTD	915..1021	CDD:368659	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840