DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrt and Frmd3

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_766457.1	Gene:	Frmd3 / 242506	MGIID:	2442466	Length:	595	Species:	Mus musculus

Alignment Length:	506	Identity:	162/506 - (32%)
Similarity:	240/506 - (47%)	Gaps:	67/506 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDAN 107
            ||.||.    :|: ::.|.:.|||::::|..:.::..|.||.|.:.....::||||||::::|..
Mouse    22 SSSIKS----LNQ-EMKCTIRLLDDSEVSCHIQRETKGQFLIEYICNYYSLLEKDYFGIRYVDPE 81

  Fly   108 HVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPED 172
            ..:|||:|.|.|.||:|..||||...:||||..||..::|||||||.:||:|:|:..|||.|...
Mouse    82 KQRHWLEPNKSIFKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFS 146

  Fly   173 KATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKT-CRGLTPAQAETAFL 236
            .|..|.|..:|:|.|||...||....:|||...|:|::.||..|::.:.. .||.:||.||...|
Mouse   147 DAAYLGACIVQAEFGDYYPDEHPENYISEFEIFPKQSQKLERKIMEIHNNELRGQSPAIAEFNLL 211

  Fly   237 NKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVI 301
            .||..|:.||||.|......|....||.|..|.:||:.:::|.|..|..:.||.|:.|  |..||
Mouse   212 LKAHTLETYGVDPHPCKDSRGATAFLGFTAAGFVVFQGNKRIHLRKWSDVCKLKFEGK--TFYVI 274

  Fly   302 EDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRL--RAPVKGPSARQNFFRMGSRFRYSG 364
            ...   :|:.....|......||||||||.||:..|::.  .:.:|..|:.:.||: ||||||||
Mouse   275 GSQ---KEKNAVLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFK-GSRFRYSG 335

  Fly   365 RTEFQTTQQSRARRTVQFERRPSQRF-----ASRQSHLLRER-------------QKASQEAAVS 411
            :...:..:.|.     :.:|.|.:..     .||..|.|.::             ....||..|.
Mouse   336 KVAKEVVEASS-----KIQRDPPEVHRVNITQSRSFHSLNKQLIINMEPLQPLLPSPTEQEEEVP 395

  Fly   412 A---------------VASVNARAAAAAAAAAASQSPAPATPLVSSQVS-------TPTP-NNDN 453
            .               :||...:.|..|......:......||..|:::       .||| ::|.
Mouse   396 VGEGVPLPKMDVSEPLIASSPVKGAQCADPPDEEEDRVKEDPLTISELAYNPSASLLPTPVDDDE 460

  Fly   454 NNDAFD-------SLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSIS 497
            .|..||       ....||.|..:....:...:.:...:.|...|.|.|.|
Mouse   461 INMLFDCPSRLELEREDTDSFEELEADENAFLIAEEEELKEARQALSWSYS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	82/190 (43%)
		FERM_N	62..124	CDD:286467	23/61 (38%)
		FERM_M	143..250	CDD:278785	47/107 (44%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	34/92 (37%)
		FA	352..392	CDD:285894	13/44 (30%)
		PHA03255	771..>924	CDD:165513
Frmd3	NP_766457.1	B41	33..225	CDD:214604	82/191 (43%)
		FERM_N	36..99	CDD:286467	23/62 (37%)
		FERM_M	117..225	CDD:278785	47/107 (44%)
		PH-like	206..309	CDD:302622	41/107 (38%)
		FA	323..>357	CDD:285894	13/39 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740