DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and EPB41L2

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_024302117.1	Gene:	EPB41L2 / 2037	HGNCID:	3379	Length:	1079	Species:	Homo sapiens

Alignment Length:	1037	Identity:	273/1037 - (26%)
Similarity:	409/1037 - (39%)	Gaps:	253/1037 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KVRNNYVDNSREGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIE 73
            ||:....| ..|||.|......|.      |:...::...|::......:.|:|.|||.|:.|.:
Human   176 KVKETQED-KLEGGAAKRETKEVQ------TNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCD 233

  Fly    74 LSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFY 138
            |.|.|.|..|:::|...|:::|||||||.|.::...|:||||.|.||:|:: ..|:.|...||||
Human   234 LEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLR-NLPWLFTFNVKFY 297

  Fly   139 SSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEHSAATVSEFR 203
            ..:|:.|.|::|||...|||:||:..|||.|.......|.:..||:||||||.:||.:..:|||:
Human   298 PPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQ 362

  Fly   204 FVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTG 268
            |.|.||::||..:.:.:||.|||:||||::.||..||.|.|||||:|.....:|.:..||:...|
Human   363 FAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANG 427

  Fly   269 ILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVE 333
            :|:::...:|..|.||||.|:.:|:....:.|...:.|  :.|.|..|:|.|.:|.|.|||..||
Human   428 LLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE--QFESTIGFKLPNHRAAKRLWKVCVE 490

  Fly   334 HHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRA--RRTVQFERRPSQRFASR--- 393
            ||||:||.:|.:.|.|:  |..:||:|||||||:.||.|.|..  |....|||..|:| .||
Human   491 HHTFYRLVSPEQPPKAK--FLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKR-VSRSLD 552

  Fly   394 -------QSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSP--APATPLVSSQVSTPTP 449
                   ...|:::...|:.|.:......|:.............:||  ||...|:..:.::...
Human   553 GAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRV 617

  Fly   450 NNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAAANFASLGRNSL 514
            ..||              |.|..|        |..:.|.|.|....:...    |:.:.|.||.:
Human   618 EGDN--------------IYVRHS--------NLMLEELDKAQEDILKHQ----ASISELKRNFM 656

  Fly   515 KSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNATSSHHGSFGKASI 579
            :|                             ||...||                    .:.|..|
Human   657 ES-----------------------------TPEPRPN--------------------EWEKRRI 672

  Fly   580 SSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDANSIRVTINKTFDMDHNTETLKRL 644
            :...|..:..|   :.|:.|:|           .:.:..:|:.....|...|:..:
Human   673 TPLSLQTQGSL---EEEITSIL-----------FSEKGFSDSMKATFTSATTWTAE--------- 714

  Fly   645 SNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMFVPAAHSSNMHTSN 709
                    ..|..||..:..|...... ::|:.|..|..|....|:        .|..|:..|.|
Human   715 --------GAVVSANAPSEKLSSSPFS-HLLETRAPESEGPCTGAR--------DAVKSSHETLN 762

  Fly   710 TNSSNNHAHSDGPD------SLNATYISVG---GDKLTLSIPEQKPSTGSSSSSSTSSTATTTTN 765
            .......|.. |.|      .:|...||.|   |:...:....||.|| |.||.|:||::.:...
Human   763 IVEEKKRAEV-GKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDST-SLSSESSSSSSESEEE 825

  Fly   766 GNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNTTLTSVTTI--------STPSSPTATVST 822
            ..|.|.                  |.:....|           ||        .....|......
Human   826 DVGEYR------------------PHHRVTEG-----------TIREEQEYEEEVEEEPRPAAKV 861

  Fly   823 TASESVAPALSNASAAEILINEIFINNIINNNASGSITAETAAKPAGSSTPSAGTLLFSTLSEQE 887
            ...|...|..|..:.|...:  |.:..:|..|..       |.|..|..:...|.|. ..:.|:.
Human   862 VEREEAVPEASPVTQAGASV--ITVETVIQENVG-------AQKIPGEKSVHEGALK-QDMGEEA 916

  Fly   888 RLESQKTNQQMNQSLNLNQNHSEVDA---------PP------------------SEKKTPSNYP 925
            ..|.||.|.::        :|.::|.         ||                  |.|:.|....
Human   917 EEEPQKVNGEV--------SHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQT 973

  Fly   926 DSSRIPFPS-------SSNSKDMVSPWLVSSEVVSAP---------KG--RESAIIRKSVIT 969
            ::..|.:.|       ..:|..:::...::||.||..         ||  .|:.|.::.|||
Human   974 ETKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVIT 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	91/189 (48%)
		FERM_N	62..124	CDD:286467	30/61 (49%)
		FERM_M	143..250	CDD:278785	53/106 (50%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/92 (38%)
		FA	352..392	CDD:285894	20/41 (49%)
		PHA03255	771..>924	CDD:165513	29/187 (16%)
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	11/52 (21%)
		B41	220..409	CDD:214604	91/189 (48%)
		FERM_C_4_1_family	404..497	CDD:270005	36/94 (38%)
		FA	507..549	CDD:312314	20/44 (45%)
		SAB	630..673	CDD:309500	13/95 (14%)
		4_1_CTD	967..1072	CDD:310467	15/69 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740