Protein Alignment yrt and EPB41

DIOPT Version :10

• Sequence 1: NP_650291.1
• Gene: yrt / 41656
• FlyBaseID: FBgn0004049
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_005245810.1
• Gene: EPB41 / 2035
• HGNCID: 3377
• Length: 1014
• Species: Homo sapiens
• Alignment Length: 833
• Identity: 227/833 - (27%)
• Similarity: 349/833 - (41%)
• Gaps: 119/833 - (14%)

  Fly    40 SGGSSQIKPQRIVVNKNK-IDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQF 103
            |...:::|..:..:.|:: :.|:|.|||:|.....:.|.|.|..|.::|...|:::|:|||||..
Human   191 SKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAI 255

  Fly   104 MDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLD 168
            .|....|.|||..|.|||||: |.|:.|...||||..:|..|.|::|||...|||:||::.|||.
Human   256 WDNATSKTWLDSAKEIKKQVR-GVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLP 319

  Fly   169 CPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAET 233
            |.......|.:..:||||||||.:.|....||:|:..|.||::||..:::.:|:.|.:|||||:.
Human   320 CSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADL 384

  Fly   234 AFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTL 298
            .||..||.|.|||||:|.....:|.:..||:..:|:||::...:|..|.|||:.|:.:|:....:
Human   385 EFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 449

  Fly   299 IVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYS 363
            .:...:.|  :.|.|..|:|.:.:|.|.|||..|||||||||.:....|.::  |..:||:||||
Human   450 KIRPGEQE--QYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK--FLALGSKFRYS 510

  Fly   364 GRTEFQTTQQSRA--RRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAA 426
            |||:.||.|.|..  |....|||..|:| |||..........|.:....::..::.....|....
Human   511 GRTQAQTRQASALIDRPAPHFERTASKR-ASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGV 574

  Fly   427 AAAS----------------------QSPAPATPLVSS---------QVSTPTPNNDNNNDAFDS 460
            ..||                      :.|..|.|..:.         :|:.||.|.|......:
Human   575 LDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAE- 638

  Fly   461 LISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAAANFASLGRNSLKSNFSNEDPAY 525
              .|:..|.:..........:|..|...:........|..:...:.||:  :.||.||....|
Human   639 --KTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASI--SELKKNFMESVP-- 697

  Fly   526 SKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNATSSHHGSFGKASIS---SGQLSV- 586
                                 .|......|.....:|||....:.....|:.||:   :.:::|
Human   698 ---------------------EPRPSEWDKRLSTHSPFRTLNINGQIPTGEGSINGIRTEEVAVV 741

  Fly   587 -KSGLSDKDRELDSLLKSIVKDPSPSVLANEAIND--ANSIRVTINKTFDMDHNTETLKRLSNAN 648
             |...::.|.|.:....|:|...|....::|::..  ..|:.::..:|   :...|......:..
Human   742 TKGPSTNPDSEWEGPKHSVVPSKSQMTTSSESLQSFAFGSLSISSKET---EEKEEGAAGYLDIK 803

  Fly   649 EKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMFVPAAHSSNMHTSNTNSS 713
            |.|..            |.|.  |          :|....|........||:...........||
Human   804 EMPRG------------PTGG--C----------IGVEEQASALKFSVTPASCQLQPGVKKAESS 844

  Fly   714 NNH-AHSDGPDSLNATYIS--VGGDKLTLSIPEQKPSTGSSSSSSTSSTATTTTNGNG-----PY 770
            ..| ...:.|...|.:::.  ||....||....|.|..       .:.|.|.:.|.|.     |.
Human   845 EEHVTPGEPPGKQNGSFLDFHVGNQFPTLIRSFQPPLV-------KTQTVTISDNANAVKSEIPT 902

  Fly   771 SNATFVSGFSAPLT-PPSSLPANLNNTGSGCNTTLTSVTTISTPSSPTATVST 822
            .:...|...:..:| ..:....|..:...|...|..::|: .||||.|.|..|
Human   903 KDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITS-ETPSSTTTTQIT 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	86/189 (46%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	33/92 (36%)
		FA	352..393	CDD:462582	21/42 (50%)
		PHA03255	771..>924	CDD:165513	13/53 (25%)
EPB41	XP_005245810.1	WTX	77..>204	CDD:462794	2/12 (17%)
		B41	211..401	CDD:214604	86/190 (45%)
		FERM_C_4_1_family	396..489	CDD:270005	35/94 (37%)
		FA	499..542	CDD:462582	22/45 (49%)
		SAB	667..715	CDD:461285	11/72 (15%)
		4_1_CTD	903..1010	CDD:461774	13/53 (25%)