Protein Alignment yrt and frm-2

DIOPT Version :9

• Sequence 1: NP_650291.1
• Gene: yrt / 41656
• FlyBaseID: FBgn0004049
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001040870.1
• Gene: frm-2 / 175848
• WormBaseID: WBGene00001489
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 592
• Identity: 252/592 - (42%)
• Similarity: 345/592 - (58%)
• Gaps: 84/592 - (14%)

  Fly     1 MLRFLSRRKVRNNYVDNSREGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILL 65
            |||.||.|..||.......:...|:..                          .|..:.|:|:||
 Worm    20 MLRSLSARFSRNRQQQQKSQTQDASFD--------------------------TKKFVQCKVLLL 58

  Fly    66 DNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYT 130
            |...|:|.:.:.|:||.|||:|||:||:.|:||||||:.|..:|:|||||||.:.|||.||||:|
 Worm    59 DGAHLNIVVPRNAVGSELYEEVFYSLDLEERDYFGLQYTDPFNVQHWLDPTKKVAKQVAIGPPFT 123

  Fly   131 FRLKVKFYSSEPNT-LREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEH 194
            .|.:|||::|||:: |:||||||.||||:|||:..|||.||...|.||.|.|||||||||:.:.|
 Worm   124 LRFRVKFFTSEPSSNLKEELTRYQFFLQIKQDISSGRLQCPHQLAIELAAFALQSELGDYNPELH 188

  Fly   195 SAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCE 259
            :|..:|||||.|||.|.:|:.||:.||.|||.||||||..:||||:|::|||||||.|.||||..
 Worm   189 TALFISEFRFHPEQDEKMEVEILERYKACRGQTPAQAELNYLNKARWIEMYGVDMHIVEGKDGNT 253

  Fly   260 YHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDE---GREQEHTFVFRLYNE 321
            |.|||||.|:|||:..||||||.|.|:.|||||.||:||:|.||.|:   |:.|.|||||.|.:|
 Worm   254 YRLGLTPQGMLVFDGPQKIGLFLWEKLQKLDFKNKKITLVVEEDADQSNNGQIQLHTFVFHLTSE 318

  Fly   322 KACKHLWKCAVEHHTFFRLRA-PVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRA----RRTVQ 381
            ||.||.||||:|.|.||||:: |::. :.:..|||:||.|:|.||||::|..:..|    |::..
 Worm   319 KAAKHFWKCAIEQHAFFRLKSRPIQA-NRKIQFFRLGSTFKYRGRTEYETIHKEGARLSRRQSCS 382

  Fly   382 FERRPSQRFASRQSHL----LRE------RQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPA 436
            ||||||||:..||||:    :|:      ||:..::...:.....:|::...:..:.....|.|.
 Worm   383 FERRPSQRYGPRQSHVTNAQIRDAKRAEMRQQIIEQQRANDQQRTHAKSDPTSPHSIIQNVPLPT 447

  Fly   437 TPLVSSQVSTPTPNNDNNNDAFDSLISTDQFIT--VTPSPSVLTVIQN-SAIIEPDAACSGSISS 498
            :|.:...|     ||.|            .||:  :|||.|..:...| |.:.:......|::.:
 Worm   448 SPDLKKPV-----NNSN------------PFISDPLTPSSSSSSSSHNLSHVTKITVGTIGNLDT 495

  Fly   499 SSQAAANFASLGRN--SLKSNFSNEDP-----AYSKIGSIGKASGL---------TVKLDPDYTP 547
            .|.:||..:.:.|.  |..::||:..|     :.|||..:..||..         .|::...:..
 Worm   496 PSSSAAPSSYIPRPVVSTSTSFSHPPPLPAHQSNSKIPRMSSASEQRKSSQPPQPAVRMQTQFEE 560

  Fly   548 P--YSPN 552
            |  ||.|
 Worm   561 PRKYSQN 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	116/190 (61%)
		FERM_N	62..124	CDD:286467	35/61 (57%)
		FERM_M	143..250	CDD:278785	67/107 (63%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	61/95 (64%)
		FA	352..392	CDD:285894	22/43 (51%)
		PHA03255	771..>924	CDD:165513
frm-2	NP_001040870.1	B41	53..244	CDD:214604	116/190 (61%)
		FERM_C_NBL4_NBL5	240..336	CDD:270007	61/95 (64%)
		FA	349..393	CDD:370090	22/43 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162468
Domainoid	1	1.000	149	1.000	Domainoid score	I2732
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I969
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003429
OrthoInspector	1	1.000	-	-		oto20732
orthoMCL	1	0.900	-	-		OOG6_108300
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4251
SonicParanoid	1	1.000	-	-		X2790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.920