DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41l4a

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_038540.2	Gene:	Epb41l4a / 13824	MGIID:	103007	Length:	686	Species:	Mus musculus

Alignment Length:	791	Identity:	219/791 - (27%)
Similarity:	350/791 - (44%)	Gaps:	155/791 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 CRVILLDNTDLSIE-----LSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPI 119
            |.|:|||.:.|::.     :.|...||.:.:.||..::::|.|||||::.|.:|..:||||.|.:
Mouse    13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFRHINLVEIDYFGLRYCDRSHQTYWLDPAKTL 77

  Fly   120 ---KKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALA 181
               |:.:..|||||....:|||:.:|..|:||:|||.||||:|||.|:|||.||.:.|.::.|.|
Mouse    78 AEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQMGAYA 142

  Fly   182 LQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYG 246
            :|:||||:|..:|:|..|||:||||:|.|:||.||...:||..|..|::||..:|..||.|:|||
Mouse   143 IQAELGDHDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQAPSEAELNYLRTAKSLEMYG 207

  Fly   247 VDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQE 311
            ||:|.|.|::..||.|||||:|::|::..:::|.:|||:|:|:.||:.:..|.|:..|.    .|
Mouse   208 VDLHPVYGENKSEYFLGLTPSGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDC----NE 268

  Fly   312 HTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGS---RFRYSGRTEFQTTQQ 373
            .:|.|...::.||||||||:||||||||: ...:..|..:...:.||   :.||||||..|.::.
Mouse   269 TSFFFEARSKTACKHLWKCSVEHHTFFRM-PDTESNSLSRKLSKFGSISYKHRYSGRTALQMSRD 332

  Fly   374 SRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATP 438
                .::|.. ||:|       :::|.|.|...:..                        |...|
Mouse   333 ----LSIQLP-RPNQ-------NVVRSRSKTYPKRV------------------------AQTQP 361

  Fly   439 LVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAA 503
            ..|:.::..|.|.:|..:...:.|       :.|||           ::.........|...|.:
Mouse   362 TGSNNINRITANTENGENEGTTKI-------IAPSP-----------VKSFKKAKNENSPDPQRS 408

  Fly   504 ANFASLGRNSLKSNF--SNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFDETNPFRNA 566
            .:.|....|..:|..  |:.|...|......:...|:...|.|.:.........|..|.:..:..
Mouse   409 KSHAPWEENGPQSGLYNSSSDRTKSPKFPCARQRNLSCGSDNDSSQLMRRRKAHNSGEDSDLKQR 473

  Fly   567 TSSHHGSFGKASISSGQLSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEAINDANSIRVTINKT 631
            ..|.    .:.:.|||..|..|....:.:...:..::.:.|..|..   ||:
Mouse   474 RRSR----SRCNTSSGSESENSNREHRKKRNRTRQENDMVDSGPQW---EAV------------- 518

  Fly   632 FDMDHNTETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMF 696
                     |:|....|:...|..:..:.:.:..|....|..:.| .:::||.............
Mouse   519 ---------LRRQKEKNQADPNNRRSRHRSRSRSPDIQAKEELWK-HIQKELVDPSGLSEEQLKE 573

  Fly   697 VPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIPEQKPSTGSSSSSSTSSTAT 761
            :|   .:.:.|........|:||  |.|..                :.:.|..|....|..|...
Mouse   574 IP---YTKVETQGDPVRIRHSHS--PRSYR----------------QYRRSQCSDGERSVLSEVN 617

  Fly   762 TTTNGNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNTT--------------LTSVTTIST 812
            :.|:                 |.||..:..:.:..|||.:|.              .:.::||:.
Mouse   618 SKTD-----------------LVPPLPVTRSSDAQGSGGSTVHQRRNGSKDSLIEEKSQLSTINP 665

  Fly   813 PSSPTA-TVST 822
            ...||| |:.|
Mouse   666 AGKPTAKTIKT 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	92/197 (47%)
		FERM_N	62..124	CDD:286467	24/69 (35%)
		FERM_M	143..250	CDD:278785	58/106 (55%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	43/92 (47%)
		FA	352..392	CDD:285894	13/42 (31%)
		PHA03255	771..>924	CDD:165513	14/67 (21%)
Epb41l4a	NP_038540.2	B41	13..211	CDD:214604	92/197 (47%)
		FERM_N	15..80	CDD:286467	23/64 (36%)
		FERM_M	105..211	CDD:278785	58/105 (55%)
		FERM_C_NBL4_NBL5	207..296	CDD:270007	43/92 (47%)
		FA	311..354	CDD:285894	16/54 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..669		70/458 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241659at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850