DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41l2

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006512569.1	Gene:	Epb41l2 / 13822	MGIID:	103009	Length:	1062	Species:	Mus musculus

Alignment Length:	1044	Identity:	269/1044 - (25%)
Similarity:	420/1044 - (40%)	Gaps:	270/1044 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKVRNNYVDNSR----EGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILLDNT 68
            ||.:...:.:::    |||.|......|.      ||...:::..|:.......:..:|.|||.|
Mouse   163 RKDKEETIQDTQEEKLEGGAAKRETKEVQ------TSELKAEVASQKATKKTKTVLAKVTLLDGT 221

  Fly    69 DLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYTFRL 133
            :.|.:|.|:|.|..|:::|...|:::|||||||.|.|....|:||||.|.||:|:| ..|:.|..
Mouse   222 EYSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWLDPAKEIKRQLK-NLPWLFTF 285

  Fly   134 KVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELCALALQSELGDYDNQEHSAAT 198
            .||||..:|:.|.|::|||...|||:||:..|||.|.......|.:..||:|.||||.:|:.:..
Mouse   286 NVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEHGDYDPEEYDSID 350

  Fly   199 VSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLG 263
            :.:|:|.|..|::||..:.:.:||.|||:||||::.||..||.|.|||||:|.....:|.:..||
Mouse   351 LGDFQFAPAHTKELEEKVSELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLG 415

  Fly   264 LTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKHLW 328
            :...|:|:::...:|..|.||||.|:.:|:....:.|...:.|  :.|.|..|:|.|.:|.|.||
Mouse   416 VCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELE--QFESTIGFKLPNHRAAKRLW 478

  Fly   329 KCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQSRA--RRTVQFERRPSQRFA 391
            |..||||||:||.:|.:.|..:  |..:||:|||||||:.||.:.|..  |...||||..|:| .
Mouse   479 KVCVEHHTFYRLVSPEQPPKTK--FLTLGSKFRYSGRTQAQTREASTLIDRPAPQFERASSKR-V 540

  Fly   392 SRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAA------------SQSPAPATPL-VSSQ 443
            ||           |.:.|...|...:.....:......            |:||..|||| ...:
Mouse   541 SR-----------SLDGAPIGVVDQSPPGEGSVPGPGVISYTTIQDGRRDSKSPTKATPLPAEGK 594

  Fly   444 VSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNS--AIIEPDAACSGSISSSSQAAANF 506
            .:|...:.||              |.|..|..:|..:..:  ||::..|:.|
Mouse   595 KNTLRVDGDN--------------IYVRHSNLMLEDLDKAQEAILKHQASIS------------- 632

  Fly   507 ASLGRNSLKSNF--SNEDPAYSKIGSIGKASGLTVKLDPDYTP-PYSPNATKNFDETNPFRNATS 568
                  .||.||  |..:|..|:...            ...|| |:.|.|:...:.|
Mouse   633 ------ELKRNFMASTPEPRPSEWEK------------RRVTPLPFQPQASLEEEIT-------- 671

  Fly   569 SHHGSFGKASISSGQ---LSVKSGLSDKDRELDSLLKSIVKDPSPSVLANEA-INDANSIRVTIN 629
                    :.:.|||   ||||:..                 ||.:....|. :.:||:.|..::
Mouse   672 --------SILFSGQGFSLSVKASF-----------------PSATTWTAEGPVVNANAPREPLS 711

  Fly   630 KTFDMDHNTETLKRLSNAN-EKPNNQVKLANVNTTALPPGNIKCNILKARVEEELGAGGNAKLTN 693
            .: ...|:.||....|... ..|.:.||.::..          .|:::.:...|:|. ..:.:|.
Mouse   712 SS-PFSHSPETRPPTSEGPCTGPRDAVKSSHET----------LNVVEEKKRAEVGK-DESVITE 764

  Fly   694 QMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKLTLSIPEQKPSTGSSSSSSTSS 758
            :|            :....|..|    ||           |:...:.....|.||..||.||:||
Mouse   765 EM------------NGKEMSPGH----GP-----------GETRKVEPVAHKDSTSLSSESSSSS 802

  Fly   759 TATTTTNGN-GPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNTTL-----TSVTTISTPSS-P 816
            :.:....|. .|:...|               ...:......|:..|     .....:...:: |
Mouse   803 SESEEDVGEYQPHHRVT---------------EGTIREEQEECDEELEEEPGQGAKVVEREAAVP 852

  Fly   817 TATVSTTASESVAPALSNASAAEILINEIFINNIINNNASGSITAETAAKPAGSSTPSAGTLLFS 881
            .|.....|..||.|                    :...|...:.|:   |..|......||
Mouse   853 DAVPDRQAGASVLP--------------------VETEAQEHVVAQ---KLPGEKGAHGGT---- 890

  Fly   882 TLSEQE-RLESQKTNQQMNQSLNLNQNHSEVDA---------PP------------------SEK 918
              :||: |.|:::...::|..:    .|.::|.         ||                  |.|
Mouse   891 --AEQDPREEAEEDPHRVNGEV----PHLDLDGLPEIICCSEPPVVKTEMVTISDASQRTEISTK 949

  Fly   919 KTPSNYPDSSRIPFPS-------SSNSKDMVSPWLVSSE---------VVSAPKG--RESAIIRK 965
            :.|....::..|.:.|       ..:|..:::...::||         :....||  .|:.|.::
Mouse   950 EVPIVQTETKTITYESPQIDGGAGGDSGVLLTAQTITSESASTTTTTHITKTVKGGISETRIEKR 1014

  Fly   966 SVIT 969
            .|||
Mouse  1015 IVIT 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	87/189 (46%)
		FERM_N	62..124	CDD:286467	31/61 (51%)
		FERM_M	143..250	CDD:278785	48/106 (45%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/92 (38%)
		FA	352..392	CDD:285894	20/41 (49%)
		PHA03255	771..>924	CDD:165513	27/186 (15%)
Epb41l2	XP_006512569.1	PTZ00121	<4..209	CDD:173412	10/51 (20%)
		B41	213..402	CDD:214604	87/189 (46%)
		FERM_C_4_1_family	397..490	CDD:270005	36/94 (38%)
		FA	500..543	CDD:400882	22/56 (39%)
		SAB	613..653	CDD:398195	12/70 (17%)
		PHA03247	<642..745	CDD:223021	28/158 (18%)
		4_1_CTD	950..1052	CDD:399118	13/69 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740