DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yrt and Epb41l1

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006498771.1	Gene:	Epb41l1 / 13821	MGIID:	103010	Length:	1602	Species:	Mus musculus

Alignment Length:	985	Identity:	272/985 - (27%)
Similarity:	389/985 - (39%)	Gaps:	248/985 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AGGGGAITSGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEK 96
            |.|....|:...:|..||:|........|||.|||.::...|:.|...|..|::.|...|:::||
Mouse    83 ADGLSERTTPSKAQKSPQKIAKKFKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEK 147

  Fly    97 DYFGLQFMDANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQD 161
            |||||.:.||:..|:||||:|.||||:: ..|:.|...||||..:|..|.|::|||...|||:.|
Mouse   148 DYFGLTYCDADSQKNWLDPSKEIKKQIR-SSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRAD 211

  Fly   162 LLEGRLDCPEDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGL 226
            ::.|||.|.......|.:.|:|:||||||.:||....|||.||.|.||.:||..|::.:||.||:
Mouse   212 IITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGM 276

  Fly   227 TPAQAETAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDF 291
            ||.:||..||..||.|.|||||:|.....:|.:..||:...|:|::....:|..|.||||.|:.:
Mouse   277 TPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISY 341

  Fly   292 KKKKLTLIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRM 356
            |:....:.:...:.|  :.|.|..|:|.|.::.|.|||..:||||||||.:|...|   :.|..|
Mouse   342 KRSNFYIKIRPGEYE--QFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPP---KGFLVM 401

  Fly   357 GSRFRYSGRTEFQTTQQSRA--RRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNAR 419
            ||:|||||||:.||.|.|..  |....|||..|:|:...:|         ...|..|..|||:..
Mouse   402 GSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRS---------LDGAEFSRPASVSEN 457

  Fly   420 AAAAAAAAAASQSPAPATPLVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSA 484
            ..|.                         |:.|...|
Mouse   458 HDAG-------------------------PDGDKRED---------------------------- 469

  Fly   485 IIEPDAACSGSISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPY 549
                ||...|..|.:.:....                                        ||
Mouse   470 ----DAESGGRRSEAEEGEVR----------------------------------------TP-- 488

  Fly   550 SPNATKNFDETNPFRNATSSHHGSF----------GKASISSGQLSVK---SGLSDKDRELD--S 599
                || ..|..|.:..|..|...|          .:|||:..:.::|   |.|..:||:.|  .
Mouse   489 ----TK-IKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWDRER 548

  Fly   600 LLKSIVKDPSPSVLANEAINDANSIRVTINKTFDMDHNTE------TLKRLSNANEKPNNQVKLA 658
            .|.|....|||.....:| ::|..|..|..:  |:...|.      |.|.|:.:.|...:.|.:.
Mouse   549 RLPSSPASPSPKGTPEKA-SEAQRIHDTSQQ--DLVPGTAAGLEVFTQKSLAASPEGSEHWVLIE 610

  Fly   659 NVNTTALPPGNIKCNILKARVEEELGAGGNAKLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPD 723
            .|.|.                .|:||.         :.|||.     ....:.||.....:||
Mouse   611 RVYTR----------------PEDLGL---------LTVPAT-----QREESGSSLTEILADG-- 643

  Fly   724 SLNATYISVGGDKLTLSIPE----QKPST-------GSSSSSSTSSTATTTTNGNGPYSNATFVS 777
            .|:...|.|...|:.::..|    |:.||       .|...|.|.........| || .:||..:
Mouse   644 RLSKVDILVDKFKVEVATEETVRAQRTSTQQQGKMIASPEGSETMREEDACLRG-GP-RDATRAA 706

  Fly   778 GFSAPLTPPSSLPANLNNTGSGCNTTLTSVTT---ISTPSS----PTATVSTTASESVAPALSNA 835
            |::      |:....|.||......|.:.|..   :..|.:    ..|.|.....|.::||....
Mouse   707 GYT------STDKLKLRNTRVSNGQTESHVELNKGLERPQTWGRLTAAGVGPVQGEVLSPASDKG 765

  Fly   836 SAAEILINEIFINNIINNNASGSITAETAAKPAGSSTPSAGTLLFSTLSEQERL----ESQKTNQ 896
            .....|::                .|:|.|:...|..        :..|..||.    ..:|.::
Mouse   766 GLQSFLLD----------------PAQTEARADSSDE--------TDTSFAERSFCLNYGKKDSE 806

  Fly   897 QMNQSLNLNQNHSEVDAPPSE--------KKTPSNYPDSS--RIPFPSSSNSKD---MVSPWLVS 948
            ....:.:|......:||||.:        ..|.:..|.||  |...|.||.:||   |.|    |
Mouse   807 DSLLAPSLGDREEHLDAPPGDGTWLELAGAHTENWEPKSSDPRASAPGSSQNKDEAHMAS----S 867

  Fly   949 SEVVSAPKGR 958
            :|...:|:.|
Mouse   868 AEEAWSPRDR 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	91/189 (48%)
		FERM_N	62..124	CDD:286467	29/61 (48%)
		FERM_M	143..250	CDD:278785	53/106 (50%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	32/92 (35%)
		FA	352..392	CDD:285894	21/41 (51%)
		PHA03255	771..>924	CDD:165513	30/171 (18%)
Epb41l1	XP_006498771.1	B41	111..300	CDD:214604	91/189 (48%)
		FERM_C_4_1_family	295..388	CDD:270005	34/94 (36%)
		FA	397..438	CDD:370090	21/40 (53%)
		SAB	506..>536	CDD:367916	5/29 (17%)
		4_1_CTD	1465..1589	CDD:368659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740