DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and Epb41l3

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_038938840.1	Gene:	Epb41l3 / 116724	RGDID:	71089	Length:	1444	Species:	Rattus norvegicus

Alignment Length:	1250	Identity:	302/1250 - (24%)
Similarity:	462/1250 - (36%)	Gaps:	381/1250 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSQI--KPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMD 105
            ||::  .|.:||.....:.|:|.|||.::...::.|::.|..|:::|...|:::|||||||.:.|
  Rat   116 SSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRD 180

  Fly   106 ANHVKHWLDPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCP 170
            |.:.|:||||.|.||||::.| .:.|...||||..:|..|.|::|||...|||:.|::.|||.|.
  Rat   181 AENQKNWLDPAKEIKKQIRSG-AWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCS 244

  Fly   171 EDKATELCALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAF 235
            ......|.:..:||||||||..|.....:|||||.|..|::||..:::.:|:.||:|||:||..|
  Rat   245 FVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHF 309

  Fly   236 LNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIV 300
            |..||.|.|||||:|.....:|.|..||:..:|:|::....:|..|.|||:.|:.:|:....:.:
  Rat   310 LENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKI 374

  Fly   301 IEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGR 365
            ...:.|  :.|.|..|:|.|.:|.|.|||..|||||||||..|...|   :.|..:||:||||||
  Rat   375 RPGEFE--QFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPP---KKFLTLGSKFRYSGR 434

  Fly   366 TEFQTTQQSRA--RRTVQFERRPSQRFA------------------------------------- 391
            |:.||.:.|..  |....|||..|:|:.
  Rat   435 TQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMKDSMSAAEVGTGQYATTKV 499

  Fly   392 ---------------SRQSHLLRE--RQKASQEAAVSAV-------------------------- 413
                           :.:.|:..|  |:||.:...|:|:
  Rat   500 ISQTNLITTVTPEKKAEEEHVEEEDRRKKAEEATPVAALRHEGKSPGHGSDSCPLSPPSAHLDPP 564

  Fly   414 --------ASVNARAAAAAA---AAAASQSPA-----------------PA---TPLVSSQVSTP 447
                    .....||:..:|   |..:|:|.|                 ||   |.|.|..:..|
  Rat   565 SPTELRRRCKEKERASPGSAVPRAELSSESDAQGKAYLGDQDVAFSYRQPAGKGTTLFSFSLQLP 629

  Fly   448 TPNNDNNNDAFDSLISTDQFITV--------------------TPS------------------- 473
                    ::|.||:..|.:::.                    :||
  Rat   630 --------ESFPSLLDEDGYLSFPNLSETNLLPQSWQHFLPIRSPSLLPCFLFIFFFLLSASFSV 686

  Fly   474 PSVLTVIQNSAI----IEP--------------------------DAACSGSISSSSQAAANFAS 508
            |..||:....|:    :||                          |.|..|..|::.......|.
  Rat   687 PYALTLSFPLALCLCFLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETSATESDQEEDAE 751

  Fly   509 L-GRNSLKSNFSNEDPAYSKIGSI-----------------------------GKASGLT----- 538
            | .:|||......|: .|.|..::                             ...:.||
  Rat   752 LKAQNSLIKRIKGEN-VYVKHSNLMLEELDKTQDELVKHQTNISELKRTFLETSTETALTNEWEK 815

  Fly   539 ------VKL-----DPDYTPPYSPNATKNFDE-----------TNPF-----------------R 564
                  |:|     |.....|..|..||...|           |:||                 .
  Rat   816 RLSTSPVRLAARQEDAPMIEPLVPEETKEEREISEKVVFLQQGTSPFLESQPSVTKKTREGVSAD 880

  Fly   565 NATSSHHGSFGKASISSGQ------------LSVKSG------------LSDKDRELDS-LLKSI 604
            :|.:||...|.|:..|:.:            ..|..|            :|.|..|:.: ||||.
  Rat   881 SAATSHQIIFQKSVPSTLEGTEDWVIVDKIPTEVVDGDSKKIVTYKVVTVSSKTGEIPADLLKSG 945

  Fly   605 VKDP-SPSVLANE-AINDANSIRV-TINKTFDMDHN---TETLK-RLSNANEKPNNQVKLANVNT 662
            :.|. ....||.| .:.:.|..:| |:.|::|....   |.|.| :.|....:|:....|..:.:
  Rat   946 MVDMYGFDDLAREMQLKEENKQKVYTLGKSYDTVSGRIVTMTGKAKDSERGPQPSTLEGLQKMES 1010

  Fly   663 TA-----LPPGNIKCNILKARVEEELGAGGNA-------KLTNQMFVPAAHSSNMHTSNTNSSNN 715
            .|     :.|..::..:|:|..|:    .|.|       :..::...|...:.:...|.......
  Rat  1011 GASEALRVGPLLVEYEVLEALTEK----SGRAPEVQTPKRRLSESLAPIKEAESRRQSPEEDDTQ 1071

  Fly   716 HA---HSDGPDSLNATYISVGGDKLTLSIPEQK--------PSTGSSS----------------- 752
            .|   ..|.|..|.::        .|..:||.:        |...|.|
  Rat  1072 KAPKLGEDAPAHLRSS--------KTQQVPECEVLKVGPFGPRRKSLSEWRYSREPAFTVATAHY 1128

  Fly   753 --SSSTSSTATTTTNGNGPYSNATFVSGFSAPLTPPSSLPANLNNTGSGCNTTLTSVTTISTPSS 815
              .||.|...|..::|......:..:|...:...|...:....:.|.|......|...||.|...
  Rat  1129 VTESSASQVVTKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVE 1193

  Fly   816 PTATVSTTASESVAPALSNASAAEILINEIFINNIINNNASG--SITAE-----TAAKPAG--SS 871
            ||......::|.|.       ...:|:.|   .:::|.:|||  |.||.     |.:.||.  |.
  Rat  1194 PTPHPQPLSTEKVL-------QETVLVEE---RHVMNVHASGDASHTARDDVDATESAPADRHSG 1248

  Fly   872 TPSAGTLLFSTLSEQERLESQKTNQQMNQSLNLNQNHSEVDA-PPSEKKTPSNYPDSSRIPFPSS 935
            ....|:.:.....||...|:.|:..:..|...::|...:|.| ..||.....::.:||.:...|.
  Rat  1249 NGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESI 1313

  Fly   936 SNSKDMVSPWLVSSE 950
            |...  |||..|..|
  Rat  1314 SVGS--VSPGGVKLE 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	86/189 (46%)
		FERM_N	62..124	CDD:286467	28/61 (46%)
		FERM_M	143..250	CDD:278785	50/106 (47%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	34/92 (37%)
		FA	352..392	CDD:285894	19/93 (20%)
		PHA03255	771..>924	CDD:165513	36/162 (22%)
Epb41l3	XP_038938840.1	B41	135..324	CDD:214604	86/189 (46%)
		FERM_C_4_1_family	319..412	CDD:270005	36/94 (38%)
		FA	421..464	CDD:400882	19/42 (45%)
		SAB	775..823	CDD:398195	2/47 (4%)
		4_1_CTD	1331..1436	CDD:399118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740