DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yrt and epb41l4b

DIOPT Version :9

Sequence 1:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_005158090.1	Gene:	epb41l4b / 100332627	ZFINID:	ZDB-GENE-100921-92	Length:	729	Species:	Danio rerio

Alignment Length:	849	Identity:	304/849 - (35%)
Similarity:	401/849 - (47%)	Gaps:	211/849 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRFL----SRRKVRNNYVDNSREGGGATSSAVGVAGGGGAITSGGSSQIKPQRIVV-------- 53
            |:.||    |||..||....:..:|       .|...||.|:......|:.....||
Zfish     1 MMGFLRRTFSRRSKRNARPPSEVDG-------TGNVRGGNAVLQAHQQQVIHAPTVVTGGAVVHI 58

  Fly    54 -----NKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFMDANHVKHWL 113
                 :|:.|.|||:|||.:|:::||.|.|.|..|::|:.|.||::|.|||||||||...|.|||
Zfish    59 PAAGNSKDAITCRVLLLDGSDVNVELPKHAKGQDLFDQIMYHLDLVEADYFGLQFMDPEQVAHWL 123

  Fly   114 DPTKPIKKQVKIGPPYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLDCPEDKATELC 178
            |..||||||::.||||....:|||||||||.|.||.|||||.|||:||:|.|:|.||.|.:.||.
Zfish   124 DAAKPIKKQIRHGPPYRLFFRVKFYSSEPNNLHEEFTRYLFVLQLRQDILSGKLKCPYDVSVELG 188

  Fly   179 ALALQSELGDYDNQEHSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAETAFLNKAKWLD 243
            |..|||||||.|..|||...||||||.|:|||.:|..|..::..|||:.|:|||..||||.|||:
Zfish   189 AYCLQSELGDCDPLEHSILLVSEFRFSPKQTEIMEADIYRKWVECRGMIPSQAELNFLNKCKWLE 253

  Fly   244 MYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLTLIVIEDDDEGR 308
            |||||||.|.|:||.||.||||||||||||...||||||||||::||||:.:|||:|:|||::||
Zfish   254 MYGVDMHFVKGRDGGEYALGLTPTGILVFEGSSKIGLFFWPKITRLDFKRNRLTLVVVEDDEKGR 318

  Fly   309 EQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRMGSRFRYSGRTEFQTTQQ 373
            ||||||||:|.:...||||||||||.|.|||||.|....::|.:|.|:|||||:|||||:|.|..
Zfish   319 EQEHTFVFQLSSSHECKHLWKCAVESHAFFRLRQPTHNKTSRSDFTRLGSRFRFSGRTEYQATHS 383

  Fly   374 SRARRTVQFERRPSQRFASRQSHLLRERQKASQEAAVSAVASVNARAAAAAAAAAASQSPAPATP 438
            .:.||...||||||:|:.||                  |.:.|.|...|.....:|..||.|:..
Zfish   384 GKVRRASTFERRPSKRYPSR------------------AQSMVKAMTPAKHPHLSAQTSPEPSLK 430

  Fly   439 LVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGSISSSSQAA 503
            .....:.                |:.|.:....|.||:.:
Zfish   431 PYKHNIP----------------IAQDPWQRSHPPPSLTS------------------------- 454

  Fly   504 ANFASLGRNSLKSNFSNEDPAYSKIGSIGKASGLTVKLDPDYTPPYSPNATKNFD-ETNPFRNAT 567
                               |.|.:...:|..       .|.::.|.|...|:.|. |.|   .|.
Zfish   455 -------------------PLYIQPMELGHT-------PPPHSFPLSAADTRRFSVEEN---EAP 490

  Fly   568 SS-------HHGSFGK------ASISSGQLSVKSGLSDK-DRELDSLLKSIVKDPS--PSVLANE 616
            .|       ||..:.|      .:.......|...|||: ||.|.:.|::   :|:  |::..|
Zfish   491 HSGKIHRCYHHHGYEKQEPLCLTTAKPKAWVVSPALSDELDRALQNQLEA---EPAAWPALHIN- 551

  Fly   617 AINDANSIRVTINKTFDMDHNTETLKRLSNANEKPNNQVKLANVNTTALPPGNIKCNILKARVEE 681
                           .||            |.|||.::..|.  ::.|:....:|.||.|...:.
Zfish   552 ---------------IDM------------AEEKPLSEKSLP--SSPAVLQEQLKSNISKRATQS 587

  Fly   682 ELG-AGGNAKLTNQMFVPAAHSSNMHTSNTNSSN----------------NHAHSDGPDSLNATY 729
            :.| :.||:...:|   ...:.|:...|.::|.|                :..|||..|
Zfish   588 DSGNSKGNSSSGDQ---TDRYPSSSQDSGSSSLNIEKPRVDRRKRLVRQFSFNHSDEDD------ 643

  Fly   730 ISVGGDKLTLSIPEQKPSTGSSSSSSTSSTATTTTNGNGPYSNATFVSGFSAPLTPPSSLPANLN 794
                       :||...:..|..|...||            ||::.......|:.||....:.|.
Zfish   644 -----------LPEALAAISSQCSMGKSS------------SNSSLDKQVQPPIYPPQKDTSRLE 685

  Fly   795 NTGS 798
            :..|
Zfish   686 HDSS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yrt	NP_650291.1	B41	60..250	CDD:214604	115/189 (61%)
		FERM_N	62..124	CDD:286467	36/61 (59%)
		FERM_M	143..250	CDD:278785	65/106 (61%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	67/92 (73%)
		FA	352..392	CDD:285894	23/39 (59%)
		PHA03255	771..>924	CDD:165513	7/28 (25%)
epb41l4b	XP_005158090.1	B41	69..260	CDD:214604	115/190 (61%)
		FERM_N	72..134	CDD:286467	36/61 (59%)
		FERM_M	153..260	CDD:278785	65/106 (61%)
		FERM_C_NBL4_NBL5	256..349	CDD:270007	67/92 (73%)
		FA	362..402	CDD:285894	23/39 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129183at33208
OrthoFinder	1	1.000	-	-		FOG0003429
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4251
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.840