DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir87a and Ir21a

DIOPT Version :9

Sequence 1:	NP_650290.2	Gene:	Ir87a / 41654	FlyBaseID:	FBgn0038153	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	153/866 - (17%)
Similarity:	279/866 - (32%)	Gaps:	286/866 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FWLAALLFLLSQHSEVRGFGINLMKVQTEDKG---QEACILALLRKYFDSGDGLSGSVLCINRNY 69
            :|:|.:|| .:|...:.|           |:.   ||.||...|..::.....:.|..:|...|
  Fly     4 YWVALVLF-TAQAFSIEG-----------DRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNN- 55

  Fly    70 QLPNIEEQLLRGVNNYENYPWSLLITNSREGPSPAKFLMN----EKPQCYFLIVDNLEDEDLDEV 130
              .|...|..|.|..::..|      ..|.....:||.:|    |:......:|:.:..|.|
  Fly    56 --ENEFRQKRRIVPTFQGNP------RPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYL--- 109

  Fly   131 FEHWKGMVNWNPLAQFVVYLASLEETDE-EMNDLMVELLLTFINKKIFNVNVIGQSEENQFYYGK 194
                      |.....:.|.:.:|::|. .:.:|...:.:||.:.:|           |..|..|
  Fly   110 ----------NKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEI-----------NADYEAK 153

  Fly   195 TV-FPYHPDNNCGNRVISV-------ELLDACDYPSEETDSEDENDEDEGDGAQEEDDGPQEEGD 251
            .. |..|.|.||.:.::.:       ::|                             |||.|..
  Fly   154 NKRFTSHIDCNCKSYILFLSDPLMTRKIL-----------------------------GPQTESR 189

  Fly   252 GEQEEEDGPQEQED----------------GDQAKGDEGQEND----------DGGLENKVENEF 290
            .............|                |:....|..:|..          ||
  Fly   190 VVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADG---------- 244

  Fly   291 RIGASDDDELENDLSSNSSEPEAIIEEFFRAKFEDKFPRDLSGCPLTASFRPWEPYIFRNSEEQP 355
             :|::....|.:.:....|.|...:       |..||....:|.....|.....|:|||
  Fly   245 -LGSNTPVVLTSWIKGALSRPHINL-------FPSKFQFGFAGHRFQISAANQPPFIFR------ 295

  Fly   356 VDDYYYGLQGDEDDYNDTSPNYGESDDESYADPGEDGDGAIPDTETQSGGKLKLSGIEYEMVQTI 420
                                                    |...::...|:|:..|:|:.::..|
  Fly   296 ----------------------------------------IRTLDSSGMGQLRWDGVEFRLLTMI 320

  Fly   421 AERLHVSIEM--QGENSN----LYHLFQQLIDGEIEMIVGGI--------------DEDPSISQF 465
            ::||:.||::  ....||    :..:.:|:|:..:::.:.||              ...|..:.|
  Fly   321 SKRLNFSIDITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAF 385

  Fly   466 V---SSSIPYHQDELTWCVARAKRRHGFFNFVATFNADAGFLIGIFVVTCSLVVWLAQRVSGF-Q 526
            :   |.::|.::..:           |.|.:.........:|.|||.:..:..:.|:..:..: :
  Fly   386 ITLASKALPKYRAIM-----------GPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE 439

  Fly   527 LRNLNGYFPTCLRVLGILLNQAIPAQDFPIT------------LRQLFALSFLMGFFFSNTYQSF 579
            :.|:..|      |.|:..|.      |..|            .|.|....:|.....::.|...
  Fly   440 VENMFWY------VFGMFTNA------FSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGS 492

  Fly   580 LISTLTTPRSS-------------YQIHTLQ----EIYSNKMTVMGTSEHVRHLNKDGEIFKYIR 627
            :|:.:|.|...             :::.||.    |.:....|.:.||...:.:...|.:.:.|.
  Fly   493 IIAFVTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIG 557

  Fly   628 EKFQMCYNLVDCLNDAAQNEHIAVAVSRQHSFYNPRI-QRDRLY----CFD--------RRESLY 679
            ...|..:.....|...||.|::.     |.:|.:..| :|..|:    ||.        .|||:|
  Fly   558 NVTQSFFWNYAFLGSKAQLEYLV-----QSNFSDENISRRSALHLSEECFALFQIGFLFPRESVY 617

  Fly   680 VYLV--TMLLPKKYHLLHQINPVIQHIIE---SGHMQKWARDLDMRRMIHEE---ITRVREDPFK 736
            ...:  .:||.::..|:.:||..:..:::   ||.:.:.:....:|.:|.||   .|...|..|.
  Fly   618 KIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFL 682

  Fly   737 ALTFDQFRGAIA----FSGGL 753
            .:....|.||.|    ..||:
  Fly   683 LMALGYFLGATALVSEIVGGI 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir87a	NP_650290.2	Periplasmic_Binding_Protein_Type_2	408..>475	CDD:304360	17/89 (19%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	59/367 (16%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	50/271 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910