DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir87a and GRIK4

DIOPT Version :9

Sequence 1:	NP_650290.2	Gene:	Ir87a / 41654	FlyBaseID:	FBgn0038153	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	239	Identity:	41/239 - (17%)
Similarity:	91/239 - (38%)	Gaps:	43/239 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 GKLKLSGIEYEMVQTIAE--RLHVSIEMQGE--------NSNLYHLFQQLIDGEIEMIVGGIDED 459
            |..:..|...:|::.:||  |.:..|.:.|:        |.....:..:||..:.::.|.|:...
Human   440 GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504

  Fly   460 PSISQFVSSSIPYHQDELTWCVARAKRRH-----GFFNFVATFNADAGFLIGIFVVTCSLVVWLA 519
            ....:.:..|.|:    :|..::...|.|     |:|:|:..|:......:.:..:..|.|::|.
Human   505 AEREKVIDFSKPF----MTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565

  Fly   520 QRVSGFQLRN------------LNGY-------FPTCLRVLGILLNQAIPAQDFPITLRQLFALS 565
            .|::.::..:            :|.|       ||     :|..:.|........::.|.:..:.
Human   566 ARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP-----VGGFMQQGSTIAPRALSTRCVSGVW 625

  Fly   566 FLMGFFFSNTYQSFLISTLTTPRSSYQIHTLQEIYSNKMTVMGT 609
            :.......::|.:.|.:.||..|....|.::.::........||
Human   626 WAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGT 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir87a	NP_650290.2	Periplasmic_Binding_Protein_Type_2	408..>475	CDD:304360	14/76 (18%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389
		ANF_receptor	43..382	CDD:279440
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	41/239 (17%)
		Lig_chan	547..816	CDD:278489	19/128 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910