DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir87a and GRID1

DIOPT Version :9

Sequence 1:	NP_650290.2	Gene:	Ir87a / 41654	FlyBaseID:	FBgn0038153	Length:	796	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	915	Identity:	152/915 - (16%)
Similarity:	281/915 - (30%)	Gaps:	327/915 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLAALLFLLSQHSEVRGFGINLMKVQTEDKGQEACILALLRKYFDSGD--GLSGSVLCINRNY-- 69
            |...::|..|:: ::||                      |:.:.|...  ||..|:..:::|.
Human   162 WQKFVMFYDSEY-DIRG----------------------LQSFLDQASRLGLDVSLQKVDKNISH 203

  Fly    70 ------------QLPNIEEQLLRGVNNYENYPWSLLITNSREGPSPAKFLMNEKPQCYFLIVDNL 122
                        :|....:.|.|.:         ||::     |..|...:||      .:..||
Human   204 VFTSLFTTMKTEELNRYRDTLRRAI---------LLLS-----PQGAHSFINE------AVETNL 248

  Fly   123 EDEDLDEVFEHWKGMVNWNPLAQFVVYLASLEETDEEMNDLMVELLLTFINKKIFNVNVIGQSEE 187
            ..:|     .||             |::      :||::|   ..:|..::..:..:.|:.|
Human   249 ASKD-----SHW-------------VFV------NEEISD---PEILDLVHSALGRMTVVRQ--- 283

  Fly   188 NQFYYGKTVFPYHPDN-NC---GNRVISVELLDACDYPSEETDSEDENDEDEGDGAQEEDDGPQE 248
                    :||...|| .|   .:|:.|:    .||
Human   284 --------IFPSAKDNQKCTRNNHRISSL----LCD----------------------------- 307

  Fly   249 EGDGEQEEEDGPQEQEDGDQAKGDEGQENDDGGLEN-KVENEFRIGASDDDELENDLSSNSSEPE 312
                       |||                 |.|:. ::.|.:..    |..|
Human   308 -----------PQE-----------------GYLQMLQISNLYLY----DSVL------------ 328

  Fly   313 AIIEEFFRAKFEDKFPRDLS--GCPLTASFRPWEPYIFRNSEEQPVD----DYYYGLQGDEDDYN 371
             ::...|..|.||:....::  .| :..|.:||      |.....:|    .:..||.|..:...
Human   329 -MLANAFHRKLEDRKWHSMASLNC-IRKSTKPW------NGGRSMLDTIKKGHITGLTGVMEFRE 385

  Fly   372 DTSPNY------GESDDESYA---------DPGEDGDGAIPD----------------------- 398
            |:|..|      |.:..|::.         |..:..:|::.:
Human   386 DSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFV 450

  Fly   399 --TETQSGGKLKLSGIEYEMVQTIAERLHVSIEM----------QGENSNLYHLFQQLIDGEIEM 451
              .|...|...:..|...:::..:|:.|....|:          |..|::...:..:||....::
Human   451 MVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADL 515

  Fly   452 IVGGIDEDPSISQFVSSSIPYHQDELTWCVARAKRRHGFFNFVATFNADAGFLIGIFVVTCSLVV 516
            .:..|...|.....|..|..|....:...:.:.:.:...|:..|.|:......|...:....:::
Human   516 AISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLI 580

  Fly   517 WLAQRVSGFQLRNLNGYFPTCLRVL--------GILLNQAIPAQDFPITLRQLFALSFLMGFFFS 573
            ::..|:...:.::.....|:....|        |..:.|...:....:.:|.:....:|......
Human   581 FVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVC 645

  Fly   574 NTYQSFLISTLTTPRSSYQIHTLQEIYSNKMTVMGTSEHVRHLNKDGEIFKYIREK--------- 629
            ::|.:.|.:.||..|....|.|.|::........||.       :|..:::|.|.|
Human   646 SSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTV-------RDSAVYEYFRAKGTNPLEQDS 703

  Fly   630 -FQMCYNLVDCLNDAAQN------EHIAVAVSRQHSFYNPRIQRDRLYCFDRRESLYVYL----- 682
             |...:..:. .|..|.|      |.|..|....::|           .:|.....|..|
Human   704 TFAELWRTIS-KNGGADNCVSSPSEGIRKAKKGNYAF-----------LWDVAVVEYAALTDDDC 756

  Fly   683 -VTM----LLPKKYHL-LHQINP----VIQHIIE---SGHM----QKW-----ARDLDMRRMIHE 725
             ||:    :..|.|.: |...:|    ..|.|:|   :|.:    |||     ..||........
Human   757 SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQA 821

  Fly   726 EITRVREDPFKALTFDQFRGAIAFSGGLLLVASCVFAFELCYVKYVYRTEKRERKTKKITKKVHN 790
            :        .|:|....|.|........||:|..|.|.||.     :.:.:..::|.|..|:| |
Human   822 D--------GKSLKLHSFAGVFCILAIGLLLACLVAALELW-----WNSNRCHQETPKEDKEV-N 872

  Fly   791 IKIQH 795
            ::..|
Human   873 LEQVH 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir87a	NP_650290.2	Periplasmic_Binding_Protein_Type_2	408..>475	CDD:304360	13/76 (17%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		69/439 (16%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	68/426 (16%)
		ANF_receptor	41..400	CDD:279440	66/403 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	64/388 (16%)
		Lig_chan	564..841	CDD:278489	52/303 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910