DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Droj2 and Dnajc21

DIOPT Version :9

Sequence 1:	NP_650283.1	Gene:	Droj2 / 41646	FlyBaseID:	FBgn0038145	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_084322.2	Gene:	Dnajc21 / 78244	MGIID:	1925371	Length:	531	Species:	Mus musculus

Alignment Length:	463	Identity:	105/463 - (22%)
Similarity:	181/463 - (39%)	Gaps:	126/463 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YYDILGVKPNATPDELKKAYRKLALKYHPDKN----PNEGEKFKAISQAYEVLSDADKRQVYDEG 67
            :|:.|||:.:|:.:|||||||||||::|||||    ....|:||.|..||:||||..:|..||..
Mouse     4 HYEALGVRRDASEEELKKAYRKLALRWHPDKNLDNAAEAAEQFKLIQAAYDVLSDPQERAWYDNH 68

  Fly    68 GEAAIKKGGADSGDFR-NPMDFFEKFFGAGFGGSGGGRRRERRGKDVVHQMSVQL---EEL---- 124
            .||.: |||.| |::: :.:|....|....:.|.|.    :.||...|:::..:|   |||
Mouse    69 REALL-KGGLD-GEYQDDSLDLLHYFTVTCYSGYGD----DERGFYAVYRVVFELIAKEELECMS 127

  Fly   125 ----------------YNGATRKLQLQKNVIC--------DKCEGRGGKKGSIEKCLQCRGNGVE 165
                            |:.............|        ::.:.|.......::.::.....:.
Mouse   128 EGDVEDFPTFGDSQSDYDTVVHPFYAHWQSFCTQKNFSWKEEYDTRQASNRWEKRAMEKENKKIR 192

  Fly   166 TRVQ----QIAPGIMQHIEQVCRKCSGTGETIQEKDRCKNCSGRKTVRERKVLEVHIEKGMRDG- 225
            .|.:    ::...::..|.:..::.....:.::|::..|.....:..|::|:.:..:.:..|:.
Mouse   193 DRARKEKNELVRQLVAFIRKRDKRVQAHRKLVEEQNAEKARKAEEMRRQQKLKQAKLAEQYREQS 257

  Fly   226 -------QKIVFTGEGDHEPESQPGDIIILLDEKEHSTFAHAGQDLMMKMPLQLVEALCGFQRIV 283
                   :|.:...|..:|.|...|.     ||.|                   ||.    |...
Mouse   258 WMTMANLEKELQEMEARYEKEFGDGS-----DENE-------------------VED----QEPR 294

  Fly   284 KTLDDRDLIVSTQPGEVIRHEMTKCIA-------EEGMPIFKNPMEKGTLIIQFEVIFPEVINPS 341
            ..||.:|   |.:..|...::...|.|       |:.|   || .||...            :..
Mouse   295 NGLDGKD---SEEAEEAELYQDLYCPACDKSFKTEKAM---KN-HEKSKK------------HRE 340

  Fly   342 VVPTLKQCLPPAPEVDIPIDAEQTVL--------EDFDPKQR-----RQQHQRMAYDEDD----G 389
            :|..|||.|....|....:..::.||        || .|||:     :::.|:.|.:.||    .
Mouse   341 MVALLKQQLEEEEEQFSGVQMDENVLNANSEEEMED-TPKQKLSKKQKKKKQKSAQNFDDNFNEN 404

  Fly   390 GYQDGPRV 397
            |.::|.::
Mouse   405 GTEEGGKI 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Droj2	NP_650283.1	PTZ00037	2..398	CDD:240236	105/463 (23%)
		DnaJ	7..65	CDD:278647	32/61 (52%)
		DnaJ_C	112..336	CDD:199909	39/273 (14%)
		DnaJ_zf	140..206	CDD:199908	6/77 (8%)
Dnajc21	NP_084322.2	DnaJ	3..66	CDD:278647	32/61 (52%)
		DBINO	<181..243	CDD:290603	5/61 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..309		13/61 (21%)
		zf-C2H2_jaz	314..339	CDD:288983	8/40 (20%)
		C2H2 Zn finger	316..338	CDD:275371	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..480		24/103 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910