DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Droj2 and Dnaja4

DIOPT Version :9

Sequence 1:	NP_650283.1	Gene:	Droj2 / 41646	FlyBaseID:	FBgn0038145	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001344804.1	Gene:	Dnaja4 / 58233	MGIID:	1927638	Length:	426	Species:	Mus musculus

Alignment Length:	407	Identity:	247/407 - (60%)
Similarity:	313/407 - (76%)	Gaps:	14/407 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKETGYYDILGVKPNATPDELKKAYRKLALKYHPDKNPNEGEKFKAISQAYEVLSDADKRQVYD 65
            |||||.|||||||||:|:|:|:|||||||||||||||||:||||||.||||||||||..||.:||
Mouse    30 MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDIYD 94

  Fly    66 EGGEAAIKKGGADSGDFRNPMDFFEKFFGAGFGGSGGGR-RRERRGKDVVHQMSVQLEELYNGAT 129
            :|||.|||:||:.|..|.:|||.|:.|||      |||| .||||||:||||:||.||:||||.|
Mouse    95 QGGEQAIKEGGSGSPSFSSPMDIFDMFFG------GGGRMTRERRGKNVVHQLSVTLEDLYNGIT 153

  Fly   130 RKLQLQKNVICDKCEGRGGKKGSIEKCLQCRGNGVETRVQQIAPGIMQHIEQVCRKCSGTGETIQ 194
            :||.|||||||:||||.||||||:|||..|:|.|::..:|||.||::|.|:.||.:|.|.||.|.
Mouse   154 KKLALQKNVICEKCEGIGGKKGSVEKCPLCKGRGMQVHIQQIGPGMVQQIQTVCIECKGQGERIN 218

  Fly   195 EKDRCKNCSGRKTVRERKVLEVHIEKGMRDGQKIVFTGEGDHEPESQPGDIIILLDEKEHSTFAH 259
            .||||:||||.|..||:|::|||:||||:|||||:|.||||.|||..|||:||:||:|:||.|..
Mouse   219 PKDRCENCSGAKVTREKKIIEVHVEKGMKDGQKILFHGEGDQEPELDPGDVIIVLDQKDHSVFQR 283

  Fly   260 AGQDLMMKMPLQLVEALCGFQRIVKTLDDRDLIVSTQPGEVIRHEMTKCIAEEGMPIFKNPMEKG 324
            .||||:|||.:||.||||||::.:||||||.|::|::.||||:|...|||..|||||:|.|:|||
Mouse   284 RGQDLIMKMKIQLSEALCGFKKTIKTLDDRVLVISSKSGEVIKHGDLKCIRNEGMPIYKAPLEKG 348

  Fly   325 TLIIQFEVIFPEV--INPSVVPTLKQCLPPAPEVDIPIDAEQTVLEDFDPKQRRQQHQRMAYDED 387
            .:||||.|:|||.  ::...:|.|:..|||..:|.|..|.:|..|::|:|.::..:..|.||:||
Mouse   349 VMIIQFLVVFPEKQWLSQEKLPQLEALLPPRQKVRITDDMDQVELKEFNPNEQSWRQHREAYEED 413

  Fly   388 DGGYQDGPRV-QQCTSS 403
            |    :.||. .||.::
Mouse   414 D----EEPRAGVQCQTA 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Droj2	NP_650283.1	PTZ00037	2..398	CDD:240236	244/399 (61%)
		DnaJ	7..65	CDD:278647	47/57 (82%)
		DnaJ_C	112..336	CDD:199909	142/223 (64%)
		DnaJ_zf	140..206	CDD:199908	39/65 (60%)
Dnaja4	NP_001344804.1	DnaJ	15..423	CDD:333066	245/402 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1273
eggNOG	1	0.900	-	-		E2759_KOG0712
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23110
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1320
Isobase	1	0.950	-	0	Normalized mean entropy	S577
OMA	1	1.010	-	-		QHG53515
OrthoDB	1	1.010	-	-		D1012379at2759
OrthoFinder	1	1.000	-	-		FOG0000718
OrthoInspector	1	1.000	-	-		otm43613
orthoMCL	1	0.900	-	-		OOG6_100614
Panther	1	1.100	-	-	LDO	PTHR43888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R684
SonicParanoid	1	1.000	-	-		X359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820