DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Droj2 and dnj-12

DIOPT Version :9

Sequence 1:	NP_650283.1	Gene:	Droj2 / 41646	FlyBaseID:	FBgn0038145	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_493570.1	Gene:	dnj-12 / 173341	WormBaseID:	WBGene00001030	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	195/411 - (47%)
Similarity:	259/411 - (63%)	Gaps:	17/411 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKETGYYDILGVKPNATPDELKKAYRKLALKYHPDKNPNEGEKFKAISQAYEVLSDADKRQVYD 65
            |||||||||:|||||:|:.:||||||||:|||:||||||:..|:||.||||||||||..|||:||
Worm     1 MVKETGYYDVLGVKPDASDNELKKAYRKMALKFHPDKNPDGAEQFKQISQAYEVLSDEKKRQIYD 65

  Fly    66 EGGEAAIKKGGADSGDFRNPMDFFEKFFGAGFGGSGGGRRRERRGKDVVHQMSVQLEELYNGATR 130
            :|||.|::.||.....|.||.|.|:.|    |||.|.|.|.|||.|..||.:.|.|:.||.|.|:
Worm    66 QGGEEALQGGGGGGEGFHNPFDVFDMF----FGGGGRGGRGERRVKPTVHNLRVTLDTLYKGVTK 126

  Fly   131 KLQLQKNVICDKCEGRGGKKGSIEKCLQCRGNGVETRVQQIAPGIMQHIEQVCRKCSGTGETIQE 195
            ||::.:...|..|:|.||.:||.::|..|||.|::.||.::.| ::|.::..|..|:|.|.|..|
Worm   127 KLKISRTATCKGCKGLGGNEGSAKECSDCRGRGIKVRVIRMGP-MVQQMQSHCDSCNGEGSTFLE 190

  Fly   196 KDRCKNCSGRKTVRERKVLEVHIEKGMRDGQKIVFTGEGDHE-PESQPGDIIILLDEKEHSTFAH 259
            |||||.|:|:|.|:|.:::||.|..||:||:|.||.|:||.. ...:|||.:::|||.||..|..
Worm   191 KDRCKKCNGKKQVKEDEIIEVGITPGMKDGEKFVFEGKGDEVIGIEKPGDFVVVLDEVEHEKFVR 255

  Fly   260 AGQDLMMKMPLQLVEALCGFQRIVKTLDDRDLIVSTQPGEVIRHEMTKCIAEEGMPIFKNPMEKG 324
            .|.:|:::..:.|.||||||.|.:.|||.|.:.....|||||.|...|.|..||||:.:...:||
Worm   256 KGDNLIIQHNIDLSEALCGFVRTISTLDGRTIFYRVLPGEVIAHADVKVIHNEGMPMRRASSDKG 320

  Fly   325 TLIIQFEVIFPEVINPSVVPTLKQCLPPAPEVDIPIDAEQTVLEDFDPKQRRQQHQRMAYDEDD- 388
            .|::||:|.||:.|||.....|...||...|..|..|||...|.:.||    |..:|...:.||
Worm   321 DLLVQFDVKFPDKINPDAAKKLADLLPGKREEIIDEDAEVVELTELDP----QASRRNFAERDDF 381

  Fly   389 ------GGYQDGPRVQQCTSS 403
                  ||:..||:..||..|
Worm   382 EGHGGFGGHGHGPQGVQCQQS 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Droj2	NP_650283.1	PTZ00037	2..398	CDD:240236	191/403 (47%)
		DnaJ	7..65	CDD:278647	42/57 (74%)
		DnaJ_C	112..336	CDD:199909	97/224 (43%)
		DnaJ_zf	140..206	CDD:199908	29/65 (45%)
dnj-12	NP_493570.1	PTZ00037	2..401	CDD:240236	193/407 (47%)
		DnaJ	7..65	CDD:278647	42/57 (74%)
		DnaJ_zf	136..201	CDD:199908	29/65 (45%)
		DnaJ_C	200..334	CDD:199909	59/133 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159742
Domainoid	1	1.000	98	1.000	Domainoid score	I4525
eggNOG	1	0.900	-	-		E2759_KOG0712
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23110
Inparanoid	1	1.050	380	1.000	Inparanoid score	I1195
Isobase	1	0.950	-	0	Normalized mean entropy	S577
OMA	1	1.010	-	-		QHG53515
OrthoDB	1	1.010	-	-		D1012379at2759
OrthoFinder	1	1.000	-	-		FOG0000718
OrthoInspector	1	1.000	-	-		oto19805
orthoMCL	1	0.900	-	-		OOG6_100614
Panther	1	1.100	-	-	LDO	PTHR43888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R684
SonicParanoid	1	1.000	-	-		X359
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790