DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8870 and MASP2

DIOPT Version :9

Sequence 1:	NP_731802.1	Gene:	CG8870 / 41645	FlyBaseID:	FBgn0038144	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	378	Identity:	100/378 - (26%)
Similarity:	142/378 - (37%)	Gaps:	104/378 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AGCQFD------------TECVNLDKCPRTR-------------AVMNSSRKNIIGLRRCGTNKV 63
            |.||.|            .:|...|..|..|             ||:..|.:......:....|.
Human   346 AVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKY 410

  Fly    64 CC--------PKWETYLP--HDTCGQSRRKPTKGKI-------PALNEFPWMAMLLYGNKNNLSQ 111
            .|        .|.|..||  ...||.|.| .|.|:|       |  .:|||..::|.|
Human   411 VCEADGFWTSSKGEKSLPVCEPVCGLSAR-TTGGRIYGGQKAKP--GDFPWQVLILGG------- 465

  Fly   112 KLVPKCGGSLINNWYVLTAAHCVEYPFMDYPYALKTVRLGEHNTSTNPDRAIVNGRRQYAPLYME 176
              ....|..|.:|| ||||||.|        |..|      |:.|....|  :...::.:|.|.:
Human   466 --TTAAGALLYDNW-VLTAAHAV--------YEQK------HDASALDIR--MGTLKRLSPHYTQ 511

  Fly   177 IEVDQIITHEQFNRGRRLINDIALVRLKFPVRYTRAIQPICLPR--AQKLAAHKRKFQASGWPDM 239
            ...:.:..||.:.......|||||::|...|.....|.||||||  |:..........||||
Human   512 AWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGW--- 573

  Fly   240 GQGIASEVLLRSFIAER--HPDV-------CKSNYD---FNLGS----QICAGGLD--GNDTSPG 286
              |:..    |.|:|..  :.|:       |.:.|:   :..||    .:|| ||:  |.|:..|
Human   574 --GLTQ----RGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCA-GLESGGKDSCRG 631

  Fly   287 DSGGPLMETVIRGKVTLTYAAGIISYGQKPCVLKTCKPAFYTKTSYFFEWIKS 339
            ||||.|:  .:..:....:..||:|:|...|. :..:...|||...:..||::
Human   632 DSGGALV--FLDSETERWFVGGIVSWGSMNCG-EAGQYGVYTKVINYIPWIEN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8870	NP_731802.1	Tryp_SPc	93..340	CDD:238113	75/267 (28%)
CG8870	NP_731802.1	Tryp_SPc	93..337	CDD:214473	73/263 (28%)
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478	4/14 (29%)
		Sushi	366..430	CDD:278512	13/63 (21%)
		Tryp_SPc	444..679	CDD:214473	75/275 (27%)
		Tryp_SPc	445..682	CDD:238113	77/278 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910