DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and TGL1

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_012782.1	Gene:	TGL1 / 853717	SGDID:	S000001623	Length:	548	Species:	Saccharomyces cerevisiae

Alignment Length:	378	Identity:	118/378 - (31%)
Similarity:	171/378 - (45%)	Gaps:	57/378 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 MERHEVVTSDNYILTMHRIPYSPKTGESSNRPVAFLMHGMLSSSSDWVL-MGPERSLAYMLADAG 102
            :|.|.|.|.||||||:||||  |.:....|..|.:|.||:|..|..|.. :...::|.::|.|.|
Yeast    77 VEDHLVRTEDNYILTLHRIP--PISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLG 139

  Fly   103 YDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPAMIDYVLAKTGQQQVQYVGHSQGT 167
            |||||||.|||.||.||...|.....||:||.:|...:|:|..|:::|..|...:|..:|.|||:
Yeast   140 YDVWMGNNRGNKYSTAHLNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGS 204

  Fly   168 TVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPLTRAFAPIL---GQPNAIVEVC-----GSM 224
            .......|...:.|.|:  :|.:               |.||.:   |..|.||:..     |.|
Yeast   205 AQMFAAFSLSEKLNRKV--SHFI---------------AIAPAMTPKGLHNRIVDTLAKSSPGFM 252

  Fly   225 EFMPSNKFKQDLGIEMCQATSP-YADMC---ANEIFLIGGYDTEQLDYELLEHIKATSPA----G 281
            ......|......:...:...| ..::|   ||:|..      ....:.:|...|..|.|    .
Yeast   253 YLFFGRKIVLPSAVIWQRTLHPTLFNLCIDIANKILF------NWKSFNILPRQKIASYAKLYST 311

  Fly   282 ASVNQNLHFCQEYNSGKFRKFD-----YTALRNPYEYGSYFPPDYKLKNAKAPVLLYYGANDWMC 341
            .||...:|:.|...|.||:.|:     ..:|..||:..: ||   ...|.|.|:||.||..|.:.
Yeast   312 TSVKSIVHWFQILRSQKFQMFEESDNMLNSLTRPYQIAN-FP---TRTNIKIPILLIYGGIDSLV 372

  Fly   342 DVSDVRKLRDELP-NMALDYLVPFEKWAHLDFIWGTEARKYVYDEVLKQMQSY 393
            |:..::|   .|| |...|  |..:.:.|||.|||.:|...|..:||:.::.:
Yeast   373 DIDVMKK---NLPFNSVFD--VKVDNYEHLDLIWGKDADTLVIAKVLRFIEFF 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	118/375 (31%)
		Abhydro_lipase	30..89	CDD:282003	23/50 (46%)
		Abhydrolase_5	74..>192	CDD:289465	44/118 (37%)
		Abhydrolase_5	<315..355	CDD:289465	14/40 (35%)
TGL1	NP_012782.1	Abhydro_lipase	66..124	CDD:397965	23/48 (48%)
TGL1	NP_012782.1	Abhydrolase_1	106..402	CDD:395444	96/327 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I1418
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1188
Isobase	1	0.950	-	0.977872	Normalized mean entropy	S1866
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm46497
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	12	11.750