DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and Lipm

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_076392.1	Gene:	Lipm / 78753	MGIID:	1926003	Length:	422	Species:	Mus musculus

Alignment Length:	365	Identity:	140/365 - (38%)
Similarity:	216/365 - (59%)	Gaps:	10/365 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ERIEDDGYPMERHEVVTSDNYILTMHRIPY-SPKTGESSNRPVAFLMHGMLSSSSDWVLMGPERS 93
            |.|:..|||.|.:||.|.|.|||:::|||. ..:..:..:|||..|.||:|..:|:|:...|..|
Mouse    51 EIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNS 115

  Fly    94 LAYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPAMIDYVLAKTGQQQV 158
            |.::|||||:||||||:||||:|:.||........||.||::|:..:|:||:|:::|.||||::|
Mouse   116 LGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKV 180

  Fly   159 QYVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPLTRAFAPILGQPNAIVEVC-G 222
            .|||:|||||:..:..|..||...|||....|.|.|.:...:||.|:    .|..|:.:::|. |
Mouse   181 YYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKYARSPGTK----FLLLPDMMIKVLFG 241

  Fly   223 SMEFMPSNKFKQDLGIEMCQATSPYADMCANEIFLIGGYDTEQLDYELLEHIKATSPAGASVNQN 287
            ..||:...:|.:.|.|.:| .......:|:|.|.|:||::|..::........|.:|||.||...
Mouse   242 RQEFLYQTRFFRQLFIYLC-GQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNI 305

  Fly   288 LHFCQEYNSGKFRKFDY-TALRNPYEYGSYFPPDYKLKNAKAPVLLYYGANDWMCDVSDVRKLRD 351
            ||:.|..|||:.|.||: :..:|..:.....|..||:::...|..::.|..||:.:..||:.|..
Mouse   306 LHWSQAVNSGELRAFDWGSETKNQEKCNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDVKTLLS 370

  Fly   352 ELPNMALDYLVPFEKWAHLDFIWGTEARKYVYDEVLKQMQ 391
            |:.|:.....:|  :|||:|||||.:|.:.||:|::..|:
Mouse   371 EVTNLIYHKNIP--EWAHVDFIWGLDAPQRVYNEIIHLMK 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	140/365 (38%)
		Abhydro_lipase	30..89	CDD:282003	25/59 (42%)
		Abhydrolase_5	74..>192	CDD:289465	57/117 (49%)
		Abhydrolase_5	<315..355	CDD:289465	11/39 (28%)
Lipm	NP_076392.1	PLN02872	50..408	CDD:215470	139/363 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831727
Domainoid	1	1.000	227	1.000	Domainoid score	I2491
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840