DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and lipa

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001015847.2	Gene:	lipa / 548564	XenbaseID:	XB-GENE-952977	Length:	409	Species:	Xenopus tropicalis

Alignment Length:	367	Identity:	142/367 - (38%)
Similarity:	207/367 - (56%)	Gaps:	12/367 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ERIEDDGYPMERHEVVTSDNYILTMHRIPYSPKTGESSNRPVAFLMHGMLSSSSDWVLMGPERSL 94
            |.|...|||.|.:||:|.|.|||:::|||:..|......:||.||.||:|:..|:||......||
Frog    51 ELIRYRGYPSEEYEVLTEDGYILSVNRIPHGVKYASEGPKPVVFLQHGLLADGSNWVTNLENNSL 115

  Fly    95 AYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPAMIDYVLAKTGQQQVQ 159
            .::|||||||||:||:||||:|:.||......:.||.||::|:...|:||::|::..||||:|:.
Frog   116 GFILADAGYDVWIGNSRGNTWSRKHKSLSPDQEEFWAFSYDELAKKDLPAVVDFITKKTGQEQIF 180

  Fly   160 YVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPLTRAFAPILG-QPNAIV-EVCG 222
            |||||||||:..:..|..|:...|||....|.|.|.:...||||.:     || .|..:: |:.|
Frog   181 YVGHSQGTTIAFIAFSSLPQLAKKIKMYFGLAPVATVKFSKSPLAK-----LGVLPEFLIEELFG 240

  Fly   223 SMEFMPSNKFKQDLGIEMCQATSPYAD-MCANEIFLIGGYDTEQLDYELLEHIKATSPAGASVNQ 286
            ..||:|.......|....|  |...|| :|.|..||:.|::.:.|:...:....:..|||.||..
Frog   241 KGEFLPQTYLITWLATHFC--THAIADELCGNIFFLLSGFNEKNLNMSRVNVYSSHCPAGTSVQN 303

  Fly   287 NLHFCQEYNSGKFRKFDYTALRNPYEYGSYFPPDYKLKNAKAPVLLYYGANDWMCDVSDVRKLRD 351
            .||:.|...||:.:.||:....|...|....||.|.:::...|..|:.|.|||:.|..||..|..
Frog   304 MLHWRQGVRSGELKAFDFGTKGNMIHYNQTTPPFYHVRDMTVPTALWTGGNDWLADRKDVALLLT 368

  Fly   352 ELPNMALDYLVPFEKWAHLDFIWGTEARKYVYDEVLKQMQSY 393
            ::.|:.....:|  .|.|||||||.:|.:.:|:|::..|:.:
Frog   369 QVSNLVYHKEIP--DWEHLDFIWGLDAPERMYNEIIAMMKKF 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	142/364 (39%)
		Abhydro_lipase	30..89	CDD:282003	27/58 (47%)
		Abhydrolase_5	74..>192	CDD:289465	56/117 (48%)
		Abhydrolase_5	<315..355	CDD:289465	13/39 (33%)
lipa	NP_001015847.2	Abhydro_lipase	49..110	CDD:282003	27/58 (47%)
		PLN02872	50..409	CDD:215470	142/367 (39%)
		Abhydrolase_5	91..>229	CDD:289465	66/142 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2899
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm47739
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080