DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and lipf

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_998569.1	Gene:	lipf / 406713	ZFINID:	ZDB-GENE-040426-2737	Length:	396	Species:	Danio rerio

Alignment Length:	397	Identity:	140/397 - (35%)
Similarity:	215/397 - (54%)	Gaps:	18/397 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKVTILLVGLGLVLAGSRPISDCG----------ERIEDDGYPMERHEVVTSDNYILTMHRIPYS 60
            |.::::::..|||..|...:...|          |.|...|||.|..||||.|.|||:::|||:.
Zfish     4 LVLSLVILTSGLVQYGQSALDGTGLDPEVNMNISEIIRHWGYPAEEFEVVTEDGYILSINRIPHG 68

  Fly    61 PKTGESSNRPVAFLMHGMLSSSSDWVLMGPERSLAYMLADAGYDVWMGNARGNTYSKAHKYWPTY 125
            .|......:||.||.||:|::.|:||...|..||.::|||||:|||:||:||||:|..|......
Zfish    69 VKNKNEEVKPVVFLQHGLLAAGSNWVTNLPNNSLGFVLADAGFDVWIGNSRGNTWSCKHVSLDPR 133

  Fly   126 WQIFWNFSWNEIGMYDVPAMIDYVLAKTGQQQVQYVGHSQGTTVYLVMVSERPEYNDKIKSAHLL 190
            .:.:|.||.:|:...|:||:|:::...|||:|:.|||||||||:..:..|..||...|||....|
Zfish   134 QKEYWKFSHDEMAKKDLPAVINFITKMTGQEQIFYVGHSQGTTIAFMAFSTMPELASKIKMFFAL 198

  Fly   191 GPAAYMGNMKSPLTRAFAPILGQPNAIV-EVCGSMEFMPSNKFKQDLGIEMCQATSPYADMCANE 254
            .|.|.:|..|||:|:    :...|..:: ::.|..:|.|.|:..:....|.| :..|.:.:|.|.
Zfish   199 APVATVGMTKSPMTK----LSVIPEFLIWDLFGQKDFFPQNELIKFFATEFC-SRKPLSVLCGNV 258

  Fly   255 IFLIGGYDTEQLDYELLEHIKATSPAGASVNQNLHFCQEYNSGKFRKFDYTALRNPYEYGSYFPP 319
            .||:.|:|.:.|:........|..|||.||...:|:.|...|.|...:||....|...|....||
Zfish   259 FFLLCGFDEKNLNMSRTPVYTAHCPAGTSVQNMIHWAQAVKSSKLMAYDYGRAGNMAHYNQSTPP 323

  Fly   320 DYKLKNAKAPVLLYYGANDWMCDVSDVRKLRDELPNMALDYLVPFEKWAHLDFIWGTEARKYVYD 384
            .|.:::...|..::.|..|.:.|..||..|..::|.:.  |....:.|.|||||||.:|.:.:|:
Zfish   324 LYNIQDMMVPTAVWSGGQDTLADPKDVALLLTQIPKLV--YKRDIKHWEHLDFIWGMDAPQEMYE 386

  Fly   385 EVLKQMQ 391
            ::::.|:
Zfish   387 KMIEIMR 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	135/377 (36%)
		Abhydro_lipase	30..89	CDD:282003	28/58 (48%)
		Abhydrolase_5	74..>192	CDD:289465	54/117 (46%)
		Abhydrolase_5	<315..355	CDD:289465	10/39 (26%)
lipf	NP_998569.1	PLN02872	4..393	CDD:215470	139/395 (35%)
		Abhydro_lipase	36..97	CDD:282003	28/60 (47%)
		Abhydrolase_5	78..242	CDD:289465	69/167 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574727
Domainoid	1	1.000	205	1.000	Domainoid score	I2877
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3034
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm26515
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810