DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and Lip4

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	169/437 - (38%)
Similarity:	246/437 - (56%)	Gaps:	53/437 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GALKVTILLVGLGLVLAG-------------------------SRPIS-DCGERIEDD------- 35
            |.:..|::.:.|.|:.:|                         .|.:: |...|:|:|
  Fly    15 GVVDCTLIALSLCLLQSGIVEGISLSLGDITLFNVNFKTPTFLGRSVAVDSNVRLENDVDPNIQE 79

  Fly    36 -------------GYPMERHEVVTSDNYILTMHRIPYSPKTGESSNRPVAFLMHGMLSSSSDWVL 87
                         |||.|.|.:.|.|.||||:|||.....|      || .|:||:|.||:.||:
  Fly    80 DSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIARPGAT------PV-LLVHGLLDSSATWVM 137

  Fly    88 MGPERSLAYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPAMIDYVLAK 152
            |||.:.|.|:|.|.||||||.|.||||||:.|..:.|:...||:|:::|:|.:|:||.:||:|..
  Fly   138 MGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILNS 202

  Fly   153 TGQQQVQYVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPLTRAFAPILGQPNAI 217
            ||..|:.|:||||||.|:.:|.||:|||.|||.....|.|.|::.:.:||:....|......:.:
  Fly   203 TGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSLV 267

  Fly   218 VEVCGSMEFMPSNKFKQDLGIEMCQATSPYADMCANEIFLIGGYDTEQLDYELLEHIKATSPAGA 282
            :::.|..||:|.|:|.......:|..|:...::|:|.|||..|:|..||:..:|..|...|||||
  Fly   268 LKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVGHSPAGA 332

  Fly   283 SVNQNLHFCQEYNSGKFRKFDYTALRNPYEYGSYFPPDYKLKNAKAPVLLYYGANDWMCDVSDVR 347
            |..|..||.|...||.||::|:..|||.:.||:..||.|.|:|.:|.|.||||.|||:....||.
  Fly   333 STKQMQHFGQLNRSGGFRQYDHGWLRNHWIYGTIDPPSYHLENVRAKVALYYGQNDWLAPPEDVE 397

  Fly   348 KLRDELPNMALDYLVPFEKWAHLDFIWGTEARKYVYDEVLKQMQSYE 394
            .|..:|||:...|||..:::.|||||||.:||:.::|.:|:.|:::|
  Fly   398 MLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	162/386 (42%)
		Abhydro_lipase	30..89	CDD:282003	28/78 (36%)
		Abhydrolase_5	74..>192	CDD:289465	62/117 (53%)
		Abhydrolase_5	<315..355	CDD:289465	18/39 (46%)
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	159/364 (44%)
		Abhydro_lipase	88..139	CDD:282003	25/57 (44%)
		Abhydrolase_5	121..>253	CDD:289465	67/132 (51%)
		Abhydrolase_5	<368..419	CDD:289465	23/50 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439473
Domainoid	1	1.000	133	1.000	Domainoid score	I1290
eggNOG	1	0.900	-	-		E2759_KOG2624
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I1354
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39202at50557
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm26515
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	P	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
	12	11.830