DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip3 and lipl-6

DIOPT Version :9

Sequence 1:	NP_477331.1	Gene:	Lip3 / 41643	FlyBaseID:	FBgn0023495	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_504755.3	Gene:	lipl-6 / 179081	WormBaseID:	WBGene00021963	Length:	591	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	142/373 - (38%)
Similarity:	205/373 - (54%)	Gaps:	9/373 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ISDCGERIEDDGYPMERHEVVTSDNYILTMHRIPY----SPKTGESSNRPVAFLMHGMLSSSSDW 85
            :.|..|.|...|||:|.|:|||.|.||||:||||:    :.|:...:.:||.||.||:|.:||.|
Worm   179 LMDVPEIITHWGYPVETHKVVTVDGYILTLHRIPHGKNETSKSASKTPKPVVFLQHGLLCTSSIW 243

  Fly    86 VLMGPERSLAYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEIGMYDVPAMIDYVL 150
            :|..|.:|..|:.||.|||||:||.|||||||.|....:..:.||.|||.|:..||:||||:|.|
Worm   244 LLNLPRQSAGYIFADQGYDVWLGNMRGNTYSKEHTRMTSADRRFWKFSWEEMARYDLPAMINYAL 308

  Fly   151 AKTGQQQVQYVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMGNMKSPLTRAFAPILGQPN 215
            ..|.:|.:.|||||||.......:||.||.:.||:....:.|.|.|.::|. |.:....|..|.|
Worm   309 KTTKRQNLYYVGHSQGALTMFAKMSEDPEMSKKIRKFFAMAPVARMSHVKG-LFQNLGQIYEQYN 372

  Fly   216 AIVEVCGSMEFMPSNKFKQDLGIEMC-QATSPYADMCANEIFLIGGYDTEQLDYELLEHIKATSP 279
            .:.:|.|..||:.:|.|.:.|....| ||.:  ..:|.|.||.:.|.::.|.:...:....|.:|
Worm   373 LVYQVFGDGEFLTNNIFTKLLTDIFCDQAVN--NPLCENFIFAVSGPNSNQFNNSRIGIYLAHNP 435

  Fly   280 AGASVNQNLHFCQEYNSGKFRKFDYTALRNPYEYGSYFPPDYKLKNAKAPVLLYYGANDWMCDVS 344
            ||.|....|||.|.....:..:||:....|...||:..||:|.::...:.:.|:|...||:.:..
Worm   436 AGTSSRNILHFAQMVKKKRMSRFDHGKDLNLKIYGAPSPPEYDIRKINSSIYLFYSDFDWLANPK 500

  Fly   345 DVRK-LRDELPNMALDYLVPFEKWAHLDFIWGTEARKYVYDEVLKQMQ 391
            ||.. |...||:..|........:.|.||:||..|||.:||:::..::
Worm   501 DVEGFLIPMLPSKTLKKATKLRDFNHNDFLWGMRARKEIYDKIINTIK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip3	NP_477331.1	PLN02872	26..392	CDD:215470	142/372 (38%)
		Abhydro_lipase	30..89	CDD:282003	31/62 (50%)
		Abhydrolase_5	74..>192	CDD:289465	57/117 (49%)
		Abhydrolase_5	<315..355	CDD:289465	11/40 (28%)
lipl-6	NP_504755.3	PLN02872	184..544	CDD:215470	141/362 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167469
Domainoid	1	1.000	220	1.000	Domainoid score	I1499
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I1723
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm4823
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840