Protein Alignment Dic1 and SLC25A27

DIOPT Version :10

• Sequence 1: NP_650279.1
• Gene: Dic1 / 41640
• FlyBaseID: FBgn0027610
• Length: 280
• Species: Drosophila melanogaster
• Sequence 2: NP_004268.3
• Gene: SLC25A27 / 9481
• HGNCID: 21065
• Length: 323
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 84/307 - (27%)
• Similarity: 148/307 - (48%)
• Gaps: 49/307 - (15%)

  Fly     6 RKSMWFFGGLASVGAAMVTHPLDLIKVTLQTQQGHLSVAQL-------IP---------KLAREQ 54
            |.|.:...|.|:..|.:.|.||||.|..|| .||..::|:|       .|         .:..|:
Human    19 RASKFLLSGCAATVAELATFPLDLTKTRLQ-MQGEAALARLGDGARESAPYRGMVRTALGIIEEE 82

  Fly    55 GVLVFYNGLSASVLRQLTYSTARFGVYEAGKKYVNTDS-----------FGGKVALAGASGLVGG 108
            |.|..:.|::.::.|.:.||..|...||..::.|...|           .||.:|     |::|.
Human    83 GFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMA-----GVIGQ 142

  Fly   109 IVGTPADMVNVRMQNDVKL----PPQQRRNYNNAFDGLVRVYRQEGFKRLFSGATAATARGILMT 169
            .:..|.|:|.|:||.:.|.    .|.:.|..::||   .::..:.|.:.|::|......|..|:.
Human   143 FLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAF---AKILAEGGIRGLWAGWVPNIQRAALVN 204

  Fly   170 IGQIAFYDQTKIYLLATPYFQDNLVTHFTASLVAGTIATTLTQPLDVLKTRSMNAKPGEFNGLWD 234
            :|.:..||..|.||:.....:||::||..:||.:|.:|:.|..|.||:|:|.|| :|.:..|...
Human   205 MGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMN-QPRDKQGRGL 268

  Fly   235 IVKHTAKL--------GPLGFFKGYVPAFVRLGPHTIITFVFLEQLR 273
            :.|.:...        |.:..:||::|:::|:.|.:::.::..|::|
Human   269 LYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIR 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic1	NP_650279.1	Mito_carr	10..92	CDD:395101	27/97 (28%)
		Mito_carr	89..184	CDD:395101	27/109 (25%)
		Mito_carr	189..278	CDD:395101	27/93 (29%)
SLC25A27	NP_004268.3	Mito_carr	20..120	CDD:395101	28/100 (28%)
		Solcar 1	21..115		27/94 (29%)
		Mito_carr	123..219	CDD:395101	26/103 (25%)
		Solcar 2	125..217		25/99 (25%)
		Mito_carr	225..317	CDD:395101	27/92 (29%)
		Solcar 3	226..317		27/91 (30%)