DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dic1 and UCP3

DIOPT Version :9

Sequence 1:NP_001287313.1 Gene:Dic1 / 41640 FlyBaseID:FBgn0027610 Length:280 Species:Drosophila melanogaster
Sequence 2:NP_003347.1 Gene:UCP3 / 7352 HGNCID:12519 Length:312 Species:Homo sapiens


Alignment Length:282 Identity:93/282 - (32%)
Similarity:145/282 - (51%) Gaps:19/282 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 FFG-GLASVGAAMVTHPLDLIKVTLQTQQGHLSV--AQLIP---------KLAREQGVLVFYNGL 63
            |.| |.|:..|.:||.|||..||.||.|..:.:|  |:|:.         .:.|.:|....||||
Human    17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGL 81

  Fly    64 SASVLRQLTYSTARFGVYEAGK-----KYVNTDSFGGKVALAGASGLVGGIVGTPADMVNVRMQN 123
            .|.:.||:::::.|.|:|::.|     |..:..|...::.....:|.:......|.|:|.||.|.
Human    82 VAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQA 146

  Fly   124 DVKL-PPQQRRNYNNAFDGLVRVYRQEGFKRLFSGATAATARGILMTIGQIAFYDQTKIYLLATP 187
            .:.| |.:..|.|:...|....:.|:||.:.|:.|......|..::...::..||..|..||...
Human   147 SIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYH 211

  Fly   188 YFQDNLVTHFTASLVAGTIATTLTQPLDVLKTRSMNAKPGE-FNGLWDIVKHTAKLGPLGFFKGY 251
            ...||...||.::..||..||.:..|:||:|||.||:.||: |:.|..::|..|:.||..|:||:
Human   212 LLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGF 276

  Fly   252 VPAFVRLGPHTIITFVFLEQLR 273
            .|:|:|||...::.||..|||:
Human   277 TPSFLRLGSWNVVMFVTYEQLK 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dic1NP_001287313.1 Mito_carr 10..92 CDD:278578 32/97 (33%)
PTZ00169 13..273 CDD:240302 91/278 (33%)
Mito_carr 89..184 CDD:278578 22/95 (23%)
Mito_carr 189..278 CDD:278578 37/86 (43%)
UCP3NP_003347.1 Mito_carr 10..110 CDD:278578 31/92 (34%)
Solcar 1 11..105 31/87 (36%)
PTZ00169 14..302 CDD:240302 93/282 (33%)
Mito_carr 112..210 CDD:278578 24/97 (25%)
Solcar 2 114..206 22/91 (24%)
Mito_carr 214..303 CDD:278578 37/85 (44%)
Solcar 3 215..300 37/84 (44%)
Purine nucleotide binding. /evidence=ECO:0000250 279..301 9/20 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0759
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D984118at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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