Protein Alignment PK2-R1 and CCKBR

DIOPT Version :9

• Sequence 1: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 99/472 - (20%)
• Similarity: 162/472 - (34%)
• Gaps: 178/472 - (37%)

  Fly    87 NGTNASTMAADSP-----VDESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYL 146
            |.::...::.:.|     ....|.|...:|: ||:||:..|.||::..:|:..:..:.|.||.:|
Human    30 NSSSVGNLSCEPPRIRGAGTRELELAIRITL-YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFL 93

  Fly   147 FNLAVSDLILLVSGIPQELYNLWYPDM---YPFTDAMCIMGSVLSEMAANATVLTITAFTVERYI 208
            .:||||||:|.|:.:|..|    .|::   :.|...:|...|.|..::.:.:.|::.|..:|||.
Human    94 LSLAVSDLLLAVACMPFTL----LPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYS 154

  Fly   209 AICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALP------------------------------- 242
            |||.|.:.......|.|.:.|.|.||.:.||.:|
Human   155 AICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWS 219

  Fly   243 --------------QAMQFSVV----YQNEGYSCTMENDFYAHVFAVSGFIFFGGP--------- 280
                          .|:.:.::    |....:....::|..:.|....|.....||
Human   220 VLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAE 284

  Fly   281 -----------------------------------------------MTA--ICVLYV------- 289
                                                           :||  :|...|
Human   285 LWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCR 349

  Fly   290 ----LIG-------VKLKRSRLLQSLPRRTF--------DANRGLNAQGRVIRMLVAVAVAFFLC 335
                .:|       |:|.|||....|...|.        .....|.|:.||:|||:.:.|.||||
Human   350 PETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLC 414

  Fly   336 WAPFH------------AQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLY 388
            |.|.:            |.|.::...::.|::                    |.:.|.|:|||:|
Human   415 WLPVYSANTWRAFDGPGAHRALSGAPISFIHL--------------------LSYASACVNPLVY 459

  Fly   389 NIMSHKFREAFKITLTR 405
            ..|..:||:|...|..|
Human   460 CFMHRRFRQACLETCAR 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	44/130 (34%)
		7tm_1	124..388	CDD:278431	82/411 (20%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:333717	92/439 (21%)
		TM helix 1	57..81	CDD:320095	9/24 (38%)
		TM helix 2	90..112	CDD:320095	11/21 (52%)
		TM helix 3	128..150	CDD:320095	4/21 (19%)
		TM helix 4	173..189	CDD:320095	6/15 (40%)
		TM helix 5	216..239	CDD:320095	1/22 (5%)
		TM helix 6	398..423	CDD:320095	12/24 (50%)
		TM helix 7	438..463	CDD:320095	8/44 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010