DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and gpr39

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_956711.1	Gene:	gpr39 / 791773	ZFINID:	ZDB-GENE-040426-1395	Length:	440	Species:	Danio rerio

Alignment Length:	441	Identity:	123/441 - (27%)
Similarity:	197/441 - (44%)	Gaps:	102/441 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VDESLTLRTALTVCYALIFVAGVLGNLIT---CIVISRNNFMHTATNFYLFNLAVSDLILLVSGI 161
            ::.|..|:..|||.|.||...|||||..|   ..|:.||.::..:...::.:||.|||::|:.|:
Zfish    13 LEPSYGLKVFLTVLYCLILSLGVLGNSATIHVAQVLQRNGYLQRSVAEHMVSLACSDLLVLLIGL 77

  Fly   162 PQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRA 225
            |.|||: :|:|.:....||.|.:.:.|.|:.:.||:|.:...::|||:|||||||...: :..|.
Zfish    78 PVELYSAIWFPFLSRSGDAACRIYNFLFELCSYATILNVATLSLERYLAICHPFRYRAL-RGGRT 141

  Fly   226 IKFIFAIWLAAFLLALPQAMQFSVVYQNEGY-------------SCTMENDFYAHVFAVSGFIFF 277
            .:.:.|.||.:.|:|||    ..|....|||             .||..:..:. ::..|.|..|
Zfish   142 RRLLLAAWLCSALVALP----LLVATGTEGYVPAGRQTPVQNLTFCTSLSQHWV-MYRTSIFTAF 201

  Fly   278 GGPMTAICVLYVLI--GVKL--KRSRLLQSLPRRTFDAN----------RGLNAQGRVIRMLVAV 328
                    |||:|:  ||..  :...|:...|....:|.          ||..::.:.|..||.:
Zfish   202 --------VLYLLVLAGVAFMCRAMILVLRAPMGPAEAGASGDHKHQSARGKASRKQTILFLVLI 258

  Fly   329 AVAFFLCWAPFHAQRLMAV----------YGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCI 383
            ..|.|:||.|...:|||..          |..:.|.:....|:|              ::||:.:
Zfish   259 VCALFVCWMPNQIRRLMTAAVPKSSWTGSYLTSYIKLHPVADSF--------------FYLSSVL 309

  Fly   384 NPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMRLQPASCSVNNNA 448
            ||:|||:.|.:||.||..||..:..|            ||.....|..:|:.:       .:||.
Zfish   310 NPMLYNLSSRQFRSAFLQTLLCRLSL------------QHANRRTLENSGASK-------SSNNT 355

  Fly   449 LEPYGSYRVVQFRCRDANHQLSLQDSIRTTTTTT-----TINSNSMAAGNG 494
            |.|     ::|   |..| ::.:..|.|:|..::     ::|:.....|.|
Zfish   356 LRP-----LLQ---RSLN-RIRMATSSRSTPPSSAERRDSLNTTDRPQGEG 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	49/131 (37%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	84/304 (28%)
gpr39	NP_956711.1	7tm_1	37..314	CDD:278431	84/304 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920