DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and ntsr1

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_021329279.1	Gene:	ntsr1 / 569344	ZFINID:	ZDB-GENE-090313-372	Length:	400	Species:	Danio rerio

Alignment Length:	385	Identity:	119/385 - (30%)
Similarity:	183/385 - (47%)	Gaps:	46/385 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LLGSTN-------GTNASTMAADSPVDESLTLRTALTVCYALIFVAGVLGNLITCIVI----SRN 135
            ||.|.|       ....|....|..|:..:..:..:||.|.::|:.|.|||.||...:    |..
Zfish    21 LLSSANRSQPFLDNETESLSEEDLDVNTDIYSKVLVTVIYVVLFLIGCLGNSITLYTLLTKKSLQ 85

  Fly   136 NFMHTATNFYLFNLAVSDLILLVSGIPQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTI 199
            |...| .:::|.:||:|||::||..:|.|||| :|....:.|.:|:|.....|.:..:.||...|
Zfish    86 NLQST-VHYHLASLAISDLLILVLCMPIELYNFIWVHHPWAFGEAVCKGYYFLRDGCSYATAFNI 149

  Fly   200 TAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNEGYSCT--MEN 262
            .:.:|||::||||||:..::...||..|.|.|:|:|:|.||.|..........|:.|.||  :.:
Zfish   150 ASLSVERFMAICHPFKAKSIMSRSRTKKLISAMWIASFFLATPMLFTMGQQLMNDEYICTTIVSS 214

  Fly   263 DFYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANR----GLNA------ 317
            .....|..::.|:.|..||..|..|..:|..:|.|      :.|.:...||    |.||
Zfish   215 ITAKTVLQLNAFLSFVVPMALISALNGVIASQLLR------MFRESAQDNRVCIIGGNATMLSVA 273

  Fly   318 --------QGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSG 374
                    ....:.:|.||.:||.:||.|:||:|||..|      :.....|..|::......:.
Zfish   274 VEPNRAQSMRHGVMVLRAVVIAFVVCWLPYHARRLMYCY------VTEWTTALYDFYHYFYMVTN 332

  Fly   375 VLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGS 434
            ||:::|:.|||:|||::|..:|:.|..|| |...|...|..|:....:|:.|....|..|
Zfish   333 VLFYVSSAINPILYNLVSANYRQIFFSTL-RYLILPCRHKKQKRVLTRHSISICSNQTFS 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	51/132 (39%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	90/288 (31%)
ntsr1	XP_021329279.1	7tmA_NTSR1	54..357	CDD:320477	101/315 (32%)
		TM helix 1	54..81	CDD:320477	10/26 (38%)
		TM helix 2	91..117	CDD:320477	12/25 (48%)
		TM helix 3	131..161	CDD:320477	9/29 (31%)
		TM helix 4	173..195	CDD:320477	11/21 (52%)
		TM helix 5	217..246	CDD:320477	8/28 (29%)
		TM helix 6	280..310	CDD:320477	12/29 (41%)
		TM helix 7	325..350	CDD:320477	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020