DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and NMUR2

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_064552.3	Gene:	NMUR2 / 56923	HGNCID:	16454	Length:	415	Species:	Homo sapiens

Alignment Length:	443	Identity:	133/443 - (30%)
Similarity:	212/443 - (47%)	Gaps:	78/443 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DKFLTHVAHLLNITTENLSNLLGSTNGTNASTMAADSPVDESLTLRTALTVCYALIFVAGVLGNL 126
            |.|..|    ||.|.|.|:.|.|              |......|  .::|.|..|||.||:||:
Human    20 DPFQKH----LNSTEEYLAFLCG--------------PRRSHFFL--PVSVVYVPIFVVGVIGNV 64

  Fly   127 ITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLW--YPDMYPFTDAMCIMGSVLSE 189
            :.|:||.::..|.|.||:|||:||||||::|:.|:|.|:|.:|  ||  :.|....|...:.|.|
Human    65 LVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYP--FLFGPVGCYFKTALFE 127

  Fly   190 MAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNE 254
            ....|::|:||..:||||:||.||||....|...||::.:..:|..:.|.:||......:.:.
Human   128 TVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFH-- 190

  Fly   255 GY-----------SCTMEND--FYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPR 306
             |           :||:...  .|..:..|:.|:|:..|||.|.|||.|:.::||:.:   ||..
Human   191 -YFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDK---SLEA 251

  Fly   307 RTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDY 371
            ...:||.....:..|.:||..:.:.|.:||||||..||...:      :....::....|.::..
Human   252 DEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSF------VEEWSESLAAVFNLVHV 310

  Fly   372 TSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMR 436
            .|||.::||:.:||::||::|.:|:.||:..:        :..|:| .|.||:          .:
Human   311 VSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI--------SSFHKQ-WHSQHD----------PQ 356

  Fly   437 LQPASCSV------NNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTTTTTTT 483
            |.||..::      .....|..|.    ||.|:.:.|...|..::.:...:.|
Human   357 LPPAQRNIFLTECHFVELTEDIGP----QFPCQSSMHNSHLPAALSSEQMSRT 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	55/129 (43%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	92/278 (33%)
NMUR2	NP_064552.3	7tm_1	62..327	CDD:278431	92/278 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.840