DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and Gpr39

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001107864.1	Gene:	Gpr39 / 288995	RGDID:	1306745	Length:	456	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	103/400 - (25%)
Similarity:	182/400 - (45%)	Gaps:	56/400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 LLGSTNGTNASTMAAD-SPVDE---SLTLRTALTVCYALIFVAGVLGNLIT---CIVISRNNFMH 139
            :..|:..:|..:...| |.|.|   :..::..||:.|.::||.|:|||.:|   ..|:.:..::.
  Rat     1 MASSSGSSNICSRVIDHSHVPEFEVATWIKITLTLVYLIVFVVGILGNSVTIRVTQVLQKKGYLQ 65

  Fly   140 TATNFYLFNLAVSDLILLVSGIPQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFT 203
            .....::.:||.||:::.:.|:|.|.|: :|.|...|.....|.:.:.|.|..:.||:|.:...:
  Rat    66 KEVTDHMISLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLS 130

  Fly   204 VERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVY------QNEGYSC---- 258
            .|||||||||||...:|...:....|..:|:.:.|:|||......:.|      .::|.:|
  Rat   131 FERYIAICHPFRYKDVSGPCQVKLLIGFVWVTSALVALPLLFAMGIEYPLANVPTHKGLNCNLSR 195

  Fly   259 TMEND-------------------FYAHVF-AVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQS 303
            |..:|                   |.:.:| |.:.::.....:..:|...:.:.:|.||..|..:
  Rat   196 TRHHDHPGDSNMSICTNLSSRWEVFQSSIFGAFAVYLVVLVSVAFMCWNMMKVLMKSKRGTLAGT 260

  Fly   304 LPR---RTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDY 365
            .|:   |..::.....|:.:.|..|..:.|...:||.|...:|:||.       .....|....|
  Rat   261 GPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAA-------AKPKHDWTKSY 318

  Fly   366 FR---ILDYTSGVLYFLSTCINPLLYNIMSHKFREAF-KITLTRQFGLARNHHHQQSQHHQHNYS 426
            |:   ||...|...::||:.:||||||:.|.:||:.| ::...|   |...|.:|:.|...: :|
  Rat   319 FKAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCR---LTLQHANQEKQQRAY-FS 379

  Fly   427 ALLRQNGSMR 436
            :....:.|.|
  Rat   380 STKNSSRSAR 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	42/131 (32%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	75/303 (25%)
Gpr39	NP_001107864.1	7tm_1	47..344	CDD:278431	75/303 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920