DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R1 and GPR39

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001499.1	Gene:	GPR39 / 2863	HGNCID:	4496	Length:	453	Species:	Homo sapiens

Alignment Length:	471	Identity:	117/471 - (24%)
Similarity:	190/471 - (40%)	Gaps:	89/471 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 STNGTNASTMAADSPVDE---SLTLRTALTVCYALIFVAGVLGNLIT---CIVISRNNFMHTATN 143
            |..|::.|.:...|.|.|   :..::..|.:.|.:|||.|:|||..|   ..|:.:..::.....
Human     5 SLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVT 69

  Fly   144 FYLFNLAVSDLILLVSGIPQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERY 207
            .::.:||.||:::.:.|:|.|.|: :|.|.........|.:.:.|.|..:.||:|.:...:.|||
Human    70 DHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERY 134

  Fly   208 IAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVY------QNEGYSCTMENDFYA 266
            ||||||||...:|...:....|..:|:.:.|:|||........|      .:.|.:|...:..:.
Human   135 IAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHH 199

  Fly   267 H------------------VFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPR------- 306
            .                  ||..|.|..|      :..|.||:.|......::|.|.:
Human   200 EQPETSNMSICTNLSSRWTVFQSSIFGAF------VVYLVVLLSVAFMCWNMMQVLMKSQKGSLA 258

  Fly   307 --------RTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFN 363
                    |..::.....|:.:.|..|..:.|...:||.|...:|:||.       .....|...
Human   259 GGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAA-------AKPKHDWTR 316

  Fly   364 DYFR---ILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNY 425
            .|||   ||...|...::||:.||||||.:.|.:||..|...|..:..|...:|.::.:.|.|:.
Human   317 SYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHST 381

  Fly   426 S------------ALLRQNGSMRLQPASCSVNNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTT 478
            :            |..||:.:.|.:....|...:..||           :..:..||| :|:...
Human   382 TDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEP-----------QSKSQSLSL-ESLEPN 434

  Fly   479 TTTTTINSNSMAAGNG 494
            :.....||   ||.||
Human   435 SGAKPANS---AAENG 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	42/131 (32%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	76/309 (25%)
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	88/336 (26%)
		TM helix 1	31..58	CDD:320263	10/26 (38%)
		TM helix 2	68..94	CDD:320263	8/25 (32%)
		TM helix 3	108..138	CDD:320263	11/29 (38%)
		TM helix 4	150..172	CDD:320263	6/21 (29%)
		TM helix 5	217..246	CDD:320263	9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..274		1/18 (6%)
		TM helix 6	276..306	CDD:320263	8/29 (28%)
		TM helix 7	323..348	CDD:320263	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..453		12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920