DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and MLNR

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001498.1	Gene:	MLNR / 2862	HGNCID:	4495	Length:	412	Species:	Homo sapiens

Alignment Length:	401	Identity:	123/401 - (30%)
Similarity:	178/401 - (44%)	Gaps:	104/401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LGST-NGTNASTMAAD------SPVDE---------SLTLRTALTVCYALIFVAGVLGNLITCIV 131
            :||. ||::....|.:      .|.||         :|...||:.:|   :||.||.||::|.::
Human     1 MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLC---LFVVGVSGNVVTVML 62

  Fly   132 ISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWYPDMYPFTDAMCIMGSVLSEMAANATV 196
            |.|...|.|.||.||.::|||||::|: |:|.:||.||....:.|...:|.:...:.|....||:
Human    63 IGRYRDMRTTTNLYLGSMAVSDLLILL-GLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATL 126

  Fly   197 LTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSV-VYQNEGYSCTM 260
            |.:||.:||||:|||.|.|...:....|....|..:|..|.|.|.|  ..|.| |.|:.|.|...
Human   127 LHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGP--FLFLVGVEQDPGISVVP 189

  Fly   261 ENDFYAHV----------------------------------------------------FAVSG 273
            ..:..|.:                                                    :..:.
Human   190 GLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTA 254

  Fly   274 FIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANRGLNAQGR------VIRMLVAVAVAF 332
            :.|.  |...:.:||.|||.:|..|       ||..   ||..|.||      .:|:|:.|.:||
Human   255 YFFL--PFLCLSILYGLIGRELWSS-------RRPL---RGPAASGRERGHRQTVRVLLVVVLAF 307

  Fly   333 FLCWAPFHAQRLMAVYGLNLINIGISRDA-FNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFR 396
            .:||.|||..|:  :|    ||...||.. |:.||.|:...   |::||..|||:|||::|.|:|
Human   308 IICWLPFHVGRI--IY----INTEDSRMMYFSQYFNIVALQ---LFYLSASINPILYNLISKKYR 363

  Fly   397 -EAFKITLTRQ 406
             .|||:.|.|:
Human   364 AAAFKLLLARK 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	50/127 (39%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	96/323 (30%)
MLNR	NP_001498.1	7tm_1	55..355	CDD:278431	96/323 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020