Protein Alignment PK2-R1 and NTSR2

DIOPT Version :10

• Sequence 1: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_036476.2
• Gene: NTSR2 / 23620
• HGNCID: 8040
• Length: 410
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 97/377 - (25%)
• Similarity: 159/377 - (42%)
• Gaps: 82/377 - (21%)

  Fly   100 VDESLTLRTALTVCYALIFVAGVLGNLITCIVISR------NNFMHTATNFYLFNLAVSDLILLV 158
            ||..|..:...|..||||:..|..||.::..|:.:      ....|     ::.:||::.|:||:
Human    25 VDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRH-----HVLSLALAGLLLLL 84

  Fly   159 SGIPQELYN-LWYPDMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKL 222
            .|:|.|||: :|:...:.|.|..|.....:.|:.|.||||::...:.||.:|:|.|.|..::...
Human    85 VGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTP 149

  Fly   223 SRAIKFIFAIWLAAFLLALPQAMQFSVVYQNE---------GYSCTM------------ENDFYA 266
            .|....:...|.|:..||||.|:.....::.|         ...||:            .|...:
Human   150 RRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVS 214

  Fly   267 HVFAVSGFIFFGG----PMTAICVLYVLIGVK----------LKRSRLLQSLP-RRTF------- 309
            .|..::...|..|    .:.|:|.........          |....||..:. ::||
Human   215 FVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVS 279

  Fly   310 -----DANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFND----- 364
                 |..| :.:..|.:::|.|:.|.:.:||.|:||:|||..|        :..||:.|
Human   280 LVRHKDVRR-IRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCY--------VPDDAWTDPLYNF 335

  Fly   365 --YFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHH 414
              ||.::..|   |:::|:.:.|||||.:|..||:.|   |.....|...||
Human   336 YHYFYMVTNT---LFYVSSAVTPLLYNAVSSSFRKLF---LEAVSSLCGEHH 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tmA_capaR	108..399	CDD:320262	89/352 (25%)
		TM helix 1	108..135	CDD:320262	9/32 (28%)
		TM helix 2	142..168	CDD:320262	10/26 (38%)
		TM helix 3	181..211	CDD:320262	10/29 (34%)
		TM helix 4	223..245	CDD:320262	7/21 (33%)
		TM helix 5	265..294	CDD:320262	5/32 (16%)
		TM helix 6	316..346	CDD:320262	11/29 (38%)
		TM helix 7	367..392	CDD:320262	8/24 (33%)
NTSR2	NP_036476.2	7tm_GPCRs	33..369	CDD:475119	89/352 (25%)
		TM helix 1	35..59	CDD:410628	9/23 (39%)
		TM helix 2	69..91	CDD:410628	8/26 (31%)
		TM helix 3	109..131	CDD:410628	6/21 (29%)
		TM helix 4	154..170	CDD:410628	5/15 (33%)
		TM helix 5	204..227	CDD:410628	3/22 (14%)
		TM helix 6	296..318	CDD:410628	8/21 (38%)
		TM helix 7	337..362	CDD:410628	10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..410		1/1 (100%)