DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R1 and trhr-1

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_491990.1	Gene:	trhr-1 / 183056	WormBaseID:	WBGene00016265	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	118/417 - (28%)
Similarity:	191/417 - (45%)	Gaps:	88/417 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IASSTMANPSESPEMLLLKNDKFLTHVAHLLNITTENLSNLLGSTNGTNASTMAADSPVDESLTL 106
            :.|:::|..|.||                   |..|.|       :||.|.  ....|:|
Worm     1 MTSASLAGISISP-------------------IVPEEL-------DGTIAP--IGTQPMD----- 32

  Fly   107 RTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWYP 171
             ..|...::.|.|.||||||:...|:.:...|.|.||.||.:||.||.:...:.:|.|:..|..|
Worm    33 -ITLAFVFSAISVIGVLGNLLVITVVLKVRGMKTPTNCYLVSLAASDTLFFFASMPHEMMYLLGP 96

  Fly   172 -DMYPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLA 235
             |.|.|....|::.:.|..:|.|.:.|:|.|||:|||..||:|::..||..:.||...|..||:.
Worm    97 NDHYLFGSLGCVLLTYLPYLAMNTSSLSILAFTIERYYGICNPYKARTMCTVKRATCIICGIWIF 161

  Fly   236 AFLLALPQAMQFSVVYQNEGYSCT--MENDFYAH--VFAVSGFIFFGGPMTAICVLYVLIGV--- 293
            :.|.........:::..:.|.||:  :|.:.:|:  ||.:...:::..|:....::|..||:
Worm   162 SMLYHSYWLFLATLIKDDIGTSCSFRLERNSHAYKIVFLLDFVLWYVLPIMCDIIIYAKIGITLS 226

  Fly   294 ----KLKRSRLLQSLPR-------RTFDANRG-------------LNAQGR--VIRMLVAVAVAF 332
                |:|:| :...:|.       :|...:.|             .:|:||  |::||..|...|
Worm   227 QCGDKIKKS-VKPKIPNEVIVEKSKTSSTSMGHYSGRDSHISGKRNSAKGRNQVVKMLAIVVAVF 290

  Fly   333 FLCWAPFHAQRLMAVYGLNLINIGISRDAFN---DYFRILDYTSGVLYFLSTCINPLLYNIMSHK 394
            .:||.|:   |.|.||     |..:|...::   |::..|..|   |.|::..|||:|||:||.:
Worm   291 AVCWLPY---RGMVVY-----NSFVSDPKYSWSPDWYINLSKT---LVFINCAINPILYNLMSAR 344

  Fly   395 FREAFKITLTRQ-----FGLARNHHHQ 416
            ||.||:..|:::     ...|.|..|:
Worm   345 FRAAFRSLLSKRKNSGFKSTALNQRHR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	49/128 (38%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	86/300 (29%)
trhr-1	NP_491990.1	7tmA_TRH-R	33..349	CDD:320126	99/327 (30%)
		TM helix 1	35..59	CDD:320126	10/23 (43%)
		TM helix 2	68..90	CDD:320126	8/21 (38%)
		TM helix 3	108..130	CDD:320126	7/21 (33%)
		TM helix 4	153..169	CDD:320126	4/15 (27%)
		TM helix 5	196..219	CDD:320126	3/22 (14%)
		TM helix 6	277..302	CDD:320126	10/27 (37%)
		TM helix 7	317..342	CDD:320126	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	157	1.000	Inparanoid score	I2906
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960