DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and C24B5.1

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_505381.2	Gene:	C24B5.1 / 179301	WormBaseID:	WBGene00016044	Length:	427	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	90/433 - (20%)
Similarity:	160/433 - (36%)	Gaps:	108/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SESPEMLL---LKNDKFLTHVAHLLNITTENLSNLLGSTNGTNA----------STMAADSPVDE 102
            |.:.::||   :::|.....:.|.||.:.|...:.:.:|:....          .|:...||..|
Worm     2 SSAAQLLLDSAVRDDDDPIFLYHHLNASLEAAKDAVNATSVKQILEAQTHYLFNDTIFGPSPAME 66

  Fly   103 SLTLRTALTVCYAL-----IFVAGVLGNLITCIVISRNNFMH-TATNFYLFNLAVSDLILLVSGI 161
            |...|:.:...|..     :|| |:.||.:..|:|..|..:: ..||.||..||....|.|:|.:
Worm    67 STPGRSLIQNLYYFYMPFCVFV-GLTGNTMVWILIRSNRMLNKLPTNVYLLCLAAMSSIFLLSLL 130

  Fly   162 P---QELYNLWYPDMYPFTDAM-------CIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQ 216
            .   :|:..:::.|:  |.|::       ||..:.|:.:...|:|..|....:||.:.:....|.
Worm   131 VFWIEEVAYIYFYDI--FQDSLLRNSYYSCIFNTFLAHVCDFASVWLIVLVGLERLLLLYRKTRG 193

  Fly   217 HTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNEGYSCTMENDF---YAHVFAVSGFIFFG 278
            .|..| :||..||    |..|.:.....:.|......|| .|.::.:|   |..:..|...|...
Worm   194 LTCEK-ARAQVFI----LLGFAMVFNGWILFVADMDEEG-QCDIKIEFVGMYQTMTIVETIICML 252

  Fly   279 GP----MTAICVLYVLIGVKLKR----------------------------------SRL---LQ 302
            .|    :|..|::...:...:|:                                  ||.   ::
Worm   253 VPSVLIITCNCLVVSKLNSHIKKNPGSPAVSFNTADVVLTTQTSAPSATLKSYTRISSRFSIDVE 317

  Fly   303 SLPRRTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAV-YGLN-------LINIGISR 359
            ..|::.....|..:.|  :.|.|:.|..||.|...|.:..|:.:: :|::       .|::|.
Worm   318 KAPKKKKKGIRYTDIQ--LTRSLLVVTWAFILLNIPNYGYRIASILFGISEQSSLMTAISLGA-- 378

  Fly   360 DAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKIT 402
                   .:..||.....|       .||...|.:.:...|.|
Worm   379 -------HVFLYTHHAFLF-------YLYIFYSPQMKRRLKPT 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	39/143 (27%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	66/326 (20%)
C24B5.1	NP_505381.2	7tm_GPCRs	77..404	CDD:391938	73/353 (21%)
		TM helix 1	77..103	CDD:341315	8/26 (31%)
		TM helix 2	111..140	CDD:341315	10/28 (36%)
		TM helix 3	158..185	CDD:341315	8/26 (31%)
		TM helix 4	197..217	CDD:341315	7/24 (29%)
		TM helix 5	239..264	CDD:341315	5/24 (21%)
		TM helix 6	329..359	CDD:341315	9/31 (29%)
		TM helix 7	372..397	CDD:341315	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010