Protein Alignment PK2-R1 and Cckbr

DIOPT Version :10

• Sequence 1: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_031653.1
• Gene: Cckbr / 12426
• MGIID: 99479
• Length: 453
• Species: Mus musculus
• Alignment Length: 462
• Identity: 117/462 - (25%)
• Similarity: 178/462 - (38%)
• Gaps: 147/462 - (31%)

  Fly    32 QSPSIGVGIGIASSTMANPSESPEMLLLKNDKFLTHVAHLLNITTE-NLSNLLGSTNGTNASTMA 95
            |.|..|.|     |::..|..|                 |||.::. |||.......||....:
Mouse    11 QGPGPGSG-----SSLCRPGVS-----------------LLNSSSAGNLSCETPRIRGTGTREL- 52

  Fly    96 ADSPVDESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSG 160
                   .||:|..|   ||:||:..|.||::..:|:..:..:.|.||.:|.:||||||:|.|:.
Mouse    53 -------ELTIRITL---YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVAC 107

  Fly   161 IPQELYNLWYPDM---YPFTDAMCIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKL 222
            :|..|    .|::   :.|...:|...|.|..::.:.:.|.:.|..:|||.|||.|.:.......
Mouse   108 MPFTL----LPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTR 168

  Fly   223 SRAIKFIFAIWLAAFLLALPQAMQFSVVYQNEG---YSC--TMENDFYAHVFAVSGFI-FFGGPM 281
            |.|.:.|.|.||.:.||.:|..: ::|| |..|   ..|  ...::....:::|...| .|..|.
Mouse   169 SHAARVILATWLLSGLLMVPYPV-YTVV-QPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPG 231

  Fly   282 TAICVLYVLIG------------------------------------------------------ 292
            ..:.|.|.||.
Mouse   232 VVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDS 296

  Fly   293 ----VKLKRSRL-LQSLPRRTFDANRG-------LNAQGRVIRMLVAVAVAFFLCWAPFH----- 340
                |:|.|||| :.:|...|.....|       |.|:.||:|||:.:.:.||:||.|.:
Mouse   297 DGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTW 361

  Fly   341 -------AQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREA 398
                   |:|.:|...::.|:             :|.||       |.|.|||:|..|..:||:|
Mouse   362 RAFDGPGARRALAGAPISFIH-------------LLSYT-------SACANPLVYCFMHRRFRQA 406

  Fly   399 FKITLTR 405
            ...|..|
Mouse   407 CLDTCAR 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tmA_capaR	108..399	CDD:320262	96/377 (25%)
		TM helix 1	108..135	CDD:320262	9/26 (35%)
		TM helix 2	142..168	CDD:320262	13/25 (52%)
		TM helix 3	181..211	CDD:320262	9/29 (31%)
		TM helix 4	223..245	CDD:320262	9/21 (43%)
		TM helix 5	265..294	CDD:320262	8/87 (9%)
		TM helix 6	316..346	CDD:320262	13/41 (32%)
		TM helix 7	367..392	CDD:320262	9/24 (38%)
Cckbr	NP_031653.1	7tm_GPCRs	55..407	CDD:475119	98/380 (26%)
		TM helix 1	57..81	CDD:320645	10/26 (38%)
		TM helix 2	90..112	CDD:320645	11/21 (52%)
		TM helix 3	128..150	CDD:320645	4/21 (19%)
		TM helix 4	173..189	CDD:320645	6/15 (40%)
		TM helix 5	216..239	CDD:320645	5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..276		0/18 (0%)
		TM helix 6	338..360	CDD:320645	8/21 (38%)
		TM helix 7	375..400	CDD:320645	10/44 (23%)