DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R1 and NMUR1

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_006047.3	Gene:	NMUR1 / 10316	HGNCID:	4518	Length:	426	Species:	Homo sapiens

Alignment Length:	367	Identity:	125/367 - (34%)
Similarity:	191/367 - (52%)	Gaps:	57/367 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DESLTLR--------TALTVC--YALIFVAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLI 155
            ||:|.|:        ..:.:|  |.||||.|.:||.:||:||.|:..|.|.||:|||:||||||:
Human    44 DEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLL 108

  Fly   156 LLVSGIPQELYNLWYPDMYPFTDAM--CIMGSVLSEMAANATVLTITAFTVERYIAICHPFRQHT 218
            :|:.|:|.|||.:|:  .|||...:  |...::|.||...|:||.:||.:||||:|:.||.:..:
Human   109 VLLVGLPLELYEMWH--NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARS 171

  Fly   219 MSKLSRAIKFIFAIWLAAFLLALPQA-----MQFSVVYQN---EGYSCTM--ENDFYAHVFAVSG 273
            |...:...:.:.|:|..|.|.:||..     .|..|..:.   :...|.:  ....|..|...:.
Human   172 MVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTA 236

  Fly   274 FIFFGGPMTAICVLYVLIGVKLKRSRLL---------QSLPRRTFDANRGLNAQGR--VIRMLVA 327
            .:||..||..:.|||:|||::|:|.|||         .:..|..:......:.:||  |.:||..
Human   237 LLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFV 301

  Fly   328 VAVAFFLCWAPFHAQRLM-AVY-----GLNLINIGISRDAFNDYFRILDYTSGVLYFLSTCINPL 386
            :.|.|.:|||||||.|:| :|.     ||:|.            |:.:...||:.::|.:..||:
Human   302 LVVVFGICWAPFHADRVMWSVVSQWTDGLHLA------------FQHVHVISGIFFYLGSAANPV 354

  Fly   387 LYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSAL 428
            ||::||.:|||.|:..|.    |....|..:.:|..|:.|.:
Human   355 LYSLMSSRFRETFQEALC----LGACCHRLRPRHSSHSLSRM 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	57/129 (44%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	100/292 (34%)
NMUR1	NP_006047.3	7tm_1	77..356	CDD:278431	100/292 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.840