DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R1 and ntsr2

DIOPT Version :9

Sequence 1:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_017949971.1	Gene:	ntsr2 / 101730337	XenbaseID:	XB-GENE-22068810	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	136/479 - (28%)
Similarity:	212/479 - (44%)	Gaps:	132/479 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 NLSNLLGSTNGTNASTMAADSPVDESLTLRTALTVCYALIFVAGVLGNLITCIVISRNNFMHT-- 140
            |||..:...|.|  |.::....||...:.:..:||.|.|||:.|.:||::|..::.:.:..|.
Frog     9 NLSLPMAEPNST--SDLSHQLDVDTHFSSKVFITVFYILIFLVGTIGNVLTIRLVLKKHNRHKLQ 71

  Fly   141 -ATNFYLFNLAVSDLILLVSGIPQELYN-LW--YPDMYPFTDAMCIMGSVLSEMAANATVLTITA 201
             ..:::|.::|:||:::|:..||.|||| :|  ||  :.|.||:|.....|.::.:.||||.||:
Frog    72 GTVHYHLVSMALSDILILLISIPIELYNFIWVHYP--WIFGDAVCRSYYFLRDICSYATVLNITS 134

  Fly   202 FTVERYIAICHPF-RQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQN---EGYS----- 257
            .:.|||:|||||. .:..|||: |..|.:..||.::.:.|:|.|....|.|:|   ||..
Frog   135 LSCERYLAICHPMTAKRIMSKM-RTKKILSVIWFSSVVFAMPMAFIMGVKYENTTPEGEEDPSSL 198

  Fly   258 -CT-MENDFYAHVF-AVSGFIFFGGPMTAI-CVLYVLIG-VKLKRSRLLQSL------PRRTFDA 311
             || :.:.....|| .|:.|:.|..|:..| |:..|.:. ::..|||...||      |:.::.|
Frog   199 ICTNLVSTATLKVFIQVNVFVSFLLPLALISCLNCVTVNQLESLRSRYFLSLHSSSKAPQASYRA 263

  Fly   312 N------------RGLNAQGRV--------------------IRMLVAVAVAFFLCWAPFHAQRL 344
            :            :.|:..|..                    |.||.|:.:|:.:||.|:||:||
Frog   264 HVSLKPVSSSPAVKKLSVAGATSKSSLTVSCEPNRIQPIQHSIYMLRAIVIAYVVCWLPYHARRL 328

  Fly   345 MAVYGLNLINIGISRD-------AFNDYFRILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKIT 402
            |..|        |..|       .|..||.:|..|   |:::|:.:||:|||::|..|||.|..|
Frog   329 MFCY--------IPDDYWTGFLYTFYHYFYMLTNT---LFYVSSAVNPILYNMVSSSFRELFLET 382

  Fly   403 LTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMRLQPASCSVNNNALEPYGSYRVVQFRCRDANH 467
            |    |.:|....||                                               .|.
Frog   383 L----GFSRRRKEQQ-----------------------------------------------LNS 396

  Fly   468 QLSLQDSIRTTTTTTTINSNSMAA 491
            .:|||.|:|:.|.|....:|...|
Frog   397 SVSLQTSLRSDTCTLHTPTNHRQA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	50/134 (37%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	97/328 (30%)
ntsr2	XP_017949971.1	7tm_GPCRs	36..379	CDD:391938	111/356 (31%)
		TM helix 1	38..63	CDD:341315	10/24 (42%)
		TM helix 2	75..97	CDD:341315	7/21 (33%)
		TM helix 3	115..137	CDD:341315	7/21 (33%)
		TM helix 4	160..176	CDD:341315	4/15 (27%)
		TM helix 5	210..233	CDD:341315	8/22 (36%)
		TM helix 6	303..328	CDD:341315	10/24 (42%)
		TM helix 7	347..372	CDD:341315	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020