Protein Alignment PK2-R2 and Nmur1

DIOPT Version :10

• Sequence 1: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: XP_017452122.1
• Gene: Nmur1 / 65276
• RGDID: 619867
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 427
• Identity: 146/427 - (34%)
• Similarity: 219/427 - (51%)
• Gaps: 80/427 - (18%)

  Fly     7 PTNSSGVLATDLQLFHNEKFLLNLTQVLNISADNLTSLLQGLEPEEL---LPTVTPMTPLSLLAT 68
            |..|:|:|:.:...| .|.|.|   :.||::.::|.  |:.|.|:::   ||
  Rat     6 PNASTGLLSCNDSEF-KEHFDL---EDLNLTHEDLR--LKYLGPQQVKQFLP------------- 51

  Fly    69 LSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNY 133
            :.|.|.|||:.|.|||.:||.||.|...|||.||||||:||:||:::|..|:|.:||.:.|  ||
  Rat    52 ICVTYLLIFVVGTLGNGLTCTVILRQKAMHTPTNFYLFSLAVSDLLVLLVGLPLELYEMQH--NY 114

  Fly   134 PFSDSI--CILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAAL 196
            ||....  |....:|.||...|:||.:||.:||||:|:.||.:..::...:...:.:.|||:.|:
  Rat   115 PFQLGAGGCYFRILLLETVCLASVLNVTALSVERYVAVVHPLQAKSVMTRTHVRRMLGAIWVFAI 179

  Fly   197 LLALPQAIQFSVVMQGM-------------GTSCTMKND--FFAHVFAVSGFLFFGGPMTAICVL 246
            |.:||     :..:.|:             ..:||:...  |:..|...:..|||..||..|.||
  Rat   180 LFSLP-----NTSLHGLSPLYVPCRGPVPDSVTCTLVRPQFFYKLVIQTTILLFFCLPMVTISVL 239

  Fly   247 YVLIGVKLKRSRLL---------QALPRRCYDVNRGISAQTR----VIRMLVAVAVAFFICWAPF 298
            |:|||::|:|.|:|         .|..|:.  .:|.|..:.|    |.:||:|:.:.|..||.||
  Rat   240 YLLIGLRLRRERILLQEEVKGRISAAARQA--SHRSIQLRDRERRQVTKMLIALVIVFGTCWVPF 302

  Fly   299 HAQRLMAVYGSTSGIESQWFNDV---FSILDYTSGVLYFLSTCINPLLYNIMSHKFREAFKVTLA 360
            ||.|||      ..:.|.|.:.:   |..:...|||..:|.:..||:|||:||.:|||:|:.||
  Rat   303 HADRLM------WSMVSHWTDGLRLAFQSVHLASGVFLYLGSAANPVLYNLMSTRFRESFRETL- 360

  Fly   361 RHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSV 397
               |||.:...|..|      |.:....|||.|..::
  Rat   361 ---GLGTRCCHRHQP------RHDSHSHLRLTTVSTL 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	117/318 (37%)
		TM helix 1	69..94	CDD:320262	13/24 (54%)
		TM helix 2	101..127	CDD:320262	15/25 (60%)
		TM helix 3	140..170	CDD:320262	14/29 (48%)
		TM helix 4	182..204	CDD:320262	7/21 (33%)
		TM helix 5	225..253	CDD:320262	13/27 (48%)
		TM helix 6	275..305	CDD:320262	14/33 (42%)
		TM helix 7	323..348	CDD:320262	9/24 (38%)
Nmur1	XP_017452122.1	7tm_GPCRs	50..356	CDD:475119	119/333 (36%)
		TM helix 1	52..76	CDD:410628	13/23 (57%)
		TM helix 2	85..107	CDD:410628	12/21 (57%)
		TM helix 3	124..146	CDD:410628	8/21 (38%)
		TM helix 4	169..185	CDD:410628	7/20 (35%)
		TM helix 5	218..241	CDD:410628	9/22 (41%)
		TM helix 6	285..307	CDD:410628	10/21 (48%)
		TM helix 7	324..349	CDD:410628	9/24 (38%)