DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R2 and PK2-R1

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_731790.1	Gene:	PK2-R1 / 41639	FlyBaseID:	FBgn0038140	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	647	Identity:	346/647 - (53%)
Similarity:	409/647 - (63%)	Gaps:	124/647 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DLQLFHNEKFLLNLTQVLNISADNLTSLLQGLEPEELLPTVTPMTP----LSLLATLSVGYALIF 77
            ::.|..|:|||.::..:|||:.:||::|| |........|:...:|    |:|...|:|.|||||
  Fly    55 EMLLLKNDKFLTHVAHLLNITTENLSNLL-GSTNGTNASTMAADSPVDESLTLRTALTVCYALIF 118

  Fly    78 IAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNYPFSDSICIL 142
            :|||||||||||||||||||||||||||||||:||:|||.||:||:|||||:||.|||:|::||:
  Fly   119 VAGVLGNLITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLWYPDMYPFTDAMCIM 183

  Fly   143 ESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFS 207
            .|||||.|||||||||||||||||||||||||||||||||||:|||||||:||.|||||||:|||
  Fly   184 GSVLSEMAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFS 248

  Fly   208 VVMQGMGTSCTMKNDFFAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNR 272
            ||.|..|.||||:|||:|||||||||:|||||||||||||||||||||||||||:||||.:|.||
  Fly   249 VVYQNEGYSCTMENDFYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPRRTFDANR 313

  Fly   273 GISAQTRVIRMLVAVAVAFFICWAPFHAQRLMAVYG---STSGIESQWFNDVFSILDYTSGVLYF 334
            |::||.||||||||||||||:|||||||||||||||   ...||....|||.|.|||||||||||
  Fly   314 GLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDYTSGVLYF 378

  Fly   335 LSTCINPLLYNIMSHKFREAFKVTLARHFGLGGKN---QGRGLPHTYSALRRNQTGSLRLHTT-- 394
            ||||||||||||||||||||||:||.|.|||...:   |.:...|.||||.| |.||:||...
  Fly   379 LSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLR-QNGSMRLQPASC 442

  Fly   395 ------------------------------DSVRTTMTSMATTTTGLNGSANGSGNGTTTGQSVR 429
                                          ||:|||     ||||.:|.::..:|||...|....
  Fly   443 SVNNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTT-----TTTTTINSNSMAAGNGVGGGAGGG 502

  Fly   430 LNRVSLDSVQMQGQNRSRQDLFDN------PRRMLQTQISQLSSVGDAHSLLEED---------- 478
            ..          |:...:|:|:..      |.||||.|:|||||:|||:||||.:
  Fly   503 GG----------GRRLRKQELYGPGPGTAVPHRMLQAQVSQLSSLGDANSLLEAEVVDRHYASGR 557

  Fly   479 -------------LQFP---GEPLQ-RQPTMCSIDELTDDLAISRSRLKLTR-ITRPPGGVTGGV 525
                         |..|   |:|.: .||.               :|||||| |:|     ...|
  Fly   558 AKRALLATKSGALLVTPPQSGDPSEVSQPA---------------TRLKLTRVISR-----RDEV 602

  Fly   526 AGGSTTGAAGSGGVSGDESSGKVRKAKVKVLKSSSPFKGLRTKFNWRARRKGSHKPHEKGAT 587
            |..||....||..:...|:           .:|:|.......||.||.||:.:..|..:|.|
  Fly   603 ANTSTPPFCGSHSLPDPET-----------CQSASVAGRSSRKFPWRKRRQKTEDPSSEGLT 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	219/263 (83%)
PK2-R1	NP_731790.1	7tm_4	114..>242	CDD:304433	110/127 (87%)
PK2-R1	NP_731790.1	7tm_1	124..388	CDD:278431	219/263 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445865
Domainoid	1	1.000	184	1.000	Domainoid score	I3341
eggNOG	1	0.900	-	-		E33208_3BGH7
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I3847
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0019694
OrthoInspector	1	1.000	-	-		mtm6488
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
	11	10.930