DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and Ntsr1

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001102437.1	Gene:	Ntsr1 / 366274	RGDID:	1306076	Length:	424	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	117/377 - (31%)
Similarity:	183/377 - (48%)	Gaps:	72/377 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YALIFIAGVLGNLITCIVISRN---NFMHTATNFYLFNLAISDMILLCSGMPQDLYN-LW--HPD 131
            |..:|:.|.:||.:|...::|.   ..:.:..:::|.:||:||:::|...||.:||| :|  ||
  Rat    71 YLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHP- 134

  Fly   132 NYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAAL 196
             :.|.|:.|.....|.:....||.|.:.:.:||||:||||||:..|:...||..|||.|||:|:.
  Rat   135 -WAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASA 198

  Fly   197 LLALPQAIQFSVVMQ---GMGTS-----CT--MKNDFFAHVFAVSGFLFFGGPMTAICVLYVLIG 251
            |||:|  :.|::.:|   |.||.     ||  :.......|..|:.|:.|..||..|.:|..:|.
  Rat   199 LLAIP--MLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIA 261

  Fly   252 VKL--------KRSRL---------------LQALPRRCYDVNRGISAQTRVIRMLVAVAVAFFI 293
            .||        ::.|:               :...|.|...:..|       :.:|.||.:||.:
  Rat   262 NKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHG-------VLVLRAVVIAFVV 319

  Fly   294 CWAPFHAQRLMAVYGSTSGIESQWFNDVFSILDY---TSGVLYFLSTCINPLLYNIMSHKFREAF 355
            ||.|:|.:|||..|.|    :.||...:|....|   .:..|:::|:.|||:|||::|..||:.|
  Rat   320 CWLPYHVRRLMFCYIS----DEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 380

  Fly   356 KVTLA------RHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTM 401
            ..|||      ||        .|....|:|. :.|...|....:|.:.|.|:
  Rat   381 LSTLACLCPGWRH--------RRKKRPTFSR-KPNSMSSNHAFSTSATRETL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	94/302 (31%)
Ntsr1	NP_001102437.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		7tm_1	81..369	CDD:278431	94/302 (31%)
		Neurotensin binding	326..349		8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020