DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PK2-R2 and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	128/468 - (27%)
Similarity:	213/468 - (45%)	Gaps:	73/468 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NSSGVLATDLQLFHNEKFLLNLTQVLNISADNLTSLLQGLEPEELLPTV-TPMTPLSLLATLSVG 72
            |.||:|||. |....|:..|.|....|.|||.      |:.|  .:|.: .|.|.:     ::|.
  Fly    25 NDSGLLATG-QGLEQEQEGLALDMGHNASADG------GIVP--YVPVLDRPETYI-----VTVL 75

  Fly    73 YALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDM--ILLCSGMPQDLYNLWHPDNYPF 135
            |.||||.|||||....|:..|:..|....|.|:.:||::|:  ||:|..:...:|.   .:::||
  Fly    76 YTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYT---QESWPF 137

  Fly   136 SDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFA---IWIAALL 197
            ..::|.:.....:.:...:|.|:||.:.|||.||.:|.|     ||......:|.   |||.|:|
  Fly   138 ERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLR-----KLQTKPLTVFTAVMIWILAIL 197

  Fly   198 LALPQAIQFSVVMQGMGTS--------CTMKNDFFAHVFAVSG--FLFFGGPMTAICVLYVLIGV 252
            |.:|..:...:....:.|:        |:...|.....|.|:|  .:::..|::.|..||:::..
  Fly   198 LGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAK 262

  Fly   253 KLKRSRLLQALPRRCYDVNRGISAQTR--VIRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIES 315
            :|..|  .:.:|.....:.....|:.|  |.||:||..|.||||:.|:|...|...:..|:   .
  Fly   263 RLHMS--ARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPTA---E 322

  Fly   316 QWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAFK-----VTLARHFGLGGKNQGRGLP 375
            :.|::.:::|........||::|:||:....:|..||:.|.     :.:.|...|...:...|:.
  Fly   323 EDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPHLRQHSTATGMM 387

  Fly   376 HTYS--ALRRN-----QTGSLR--LHTTDSVRTTMTSMATTTTGLNGSANGSGNGTTTGQSVRLN 431
            ...|  ::||:     ..|:||  ||            ..:..|:.|:..|.|.|..:|:....:
  Fly   388 DNTSVMSMRRSTYVGGTAGNLRASLH------------RNSNHGVGGAGGGVGGGVGSGRVGSFH 440

  Fly   432 RVSLDSVQMQGQN 444
            |  .||:.:|..|
  Fly   441 R--QDSMPLQHGN 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	74/277 (27%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	86/309 (28%)
		TM helix 1	71..97	CDD:320593	12/30 (40%)
		TM helix 2	104..130	CDD:320593	8/25 (32%)
		TM helix 3	142..172	CDD:320593	9/29 (31%)
		TM helix 4	182..202	CDD:320593	7/19 (37%)
		TM helix 5	234..259	CDD:320593	7/24 (29%)
		TM helix 6	285..315	CDD:320593	14/29 (48%)
		TM helix 7	330..355	CDD:320593	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840