DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and Cckbr

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_037297.2	Gene:	Cckbr / 25706	RGDID:	2290	Length:	452	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	107/425 - (25%)
Similarity:	164/425 - (38%)	Gaps:	130/425 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLNLTQVLNISADNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVI 91
            |||.:...|:|.          ||..:..|.|....:::..||   ||:||:..|.||::..:|:
  Rat    28 LLNSSSAGNLSC----------EPPRIRGTGTRELEMAIRITL---YAVIFLMSVGGNVLIIVVL 79

  Fly    92 SRNNFMHTATNFYLFNLAISDMILLCSGMPQDLY-NLWHPDNYPFSDSICILESVLSETAANATV 155
            ..:..:.|.||.:|.:||:||::|..:.||..|. ||.  ..:.|...||...|.|...:.:.:.
  Rat    80 GLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM--GTFIFGTVICKAISYLMGVSVSVST 142

  Fly   156 LTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSV------VMQGM- 213
            |.:.|..:|||.|||.|.:.......|.|.:.|.|.|:.:.||.:|..:...|      |:|.|
  Rat   143 LNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMH 207

  Fly   214 -GTSCTMKNDFFAHVFAVSGFLFFGGPMTAICVLYVLIG-------------------------- 251
             ..|..::..:...:.    .|.|..|...|.|.|.||.
  Rat   208 RWPSARVQQTWSVLLL----LLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGG 268

  Fly   252 -------------------------------VKLKRSRLLQAL-----------PRRCYDVNRG- 273
                                           |:|.||||....           ||    .|:.
  Rat   269 LPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPR----PNQAK 329

  Fly   274 ISAQTRVIRMLVAVAVAFFICWAPFH------------AQRLMAVYGSTSGIESQWFNDVFSILD 326
            :.|:.||:|||:.:.:.||:||.|.:            |||.:      ||....:.:
  Rat   330 LLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRAL------SGAPISFIH------- 381

  Fly   327 YTSGVLYFLSTCINPLLYNIMSHKFREAFKVTLAR 361
                :|.::|.|:|||:|..|..:||:|...|.||
  Rat   382 ----LLSYVSACVNPLVYCFMHRRFRQACLDTCAR 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	83/350 (24%)
Cckbr	NP_037297.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		7tm_GPCRs	55..406	CDD:421689	94/380 (25%)
		TM helix 1	56..82	CDD:410628	10/28 (36%)
		TM helix 2	89..115	CDD:410628	11/25 (44%)
		TM helix 3	127..157	CDD:410628	9/29 (31%)
		TM helix 4	170..191	CDD:410628	7/20 (35%)
		TM helix 5	215..244	CDD:410628	8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..286		0/28 (0%)
		TM helix 6	331..361	CDD:410628	11/29 (38%)
		TM helix 7	374..399	CDD:410628	8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..452
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100