DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and Ghsr

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_017175002.1	Gene:	Ghsr / 208188	MGIID:	2441906	Length:	427	Species:	Mus musculus

Alignment Length:	354	Identity:	131/354 - (37%)
Similarity:	170/354 - (48%)	Gaps:	54/354 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NLTSLLQGLEPEELLPTVT-------------------PMTPLSLLATLSVGYALIFIAGVLGNL 85
            |:.:.....|||   |.||                   |:.|..|||.::.....:|:.|:.|||
Mouse    63 NMWNATPSEEPE---PNVTLDLDWDASPGNDSLSDELLPLFPAPLLAGVTATCVALFVVGISGNL 124

  Fly    86 ITCIVISRNNFMHTATNFYLFNLAISD-MILLCSGMPQDLYNLWHPDNYPFSDSICILESVLSET 149
            :|.:|:||...:.|.||.||.::|.|| :|.||  ||.||..||....:.|.|.:|.|...:||:
Mouse   125 LTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLC--MPLDLVRLWQYRPWNFGDLLCKLFQFVSES 187

  Fly   150 AANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVVMQGMG 214
            ...||||||||.:||||.|||.|.|...:....|....|..||..|...|.|..:...|..:. |
Mouse   188 CTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHEN-G 251

  Fly   215 TSCTMKNDFFAHVFAV-SGFL---------FFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYD 269
            |.....|:..|..||| ||.|         ||..|:..:.|||.|||.||.|.|...|:.....|
Mouse   252 TDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGSSLRD 316

  Fly   270 VNRGISAQTRVIRMLVAVAVAFFICWAPFHAQR-LMAVYGSTSGIE----SQWFNDVFSILDYTS 329
            .|     ..:.::||..|..||.:||.|||..| |.:.......:|    ||:.|.|       |
Mouse   317 QN-----HKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLV-------S 369

  Fly   330 GVLYFLSTCINPLLYNIMSHKFREA-FKV 357
            .||::||..|||:||||||.|:|.| ||:
Mouse   370 FVLFYLSAAINPILYNIMSKKYRVAVFKL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	106/276 (38%)
Ghsr	XP_017175002.1	7tmA_GHSR	107..395	CDD:320259	116/302 (38%)
		TM helix 1	108..132	CDD:320259	7/23 (30%)
		TM helix 2	141..162	CDD:320259	11/22 (50%)
		TM helix 3	179..201	CDD:320259	11/21 (52%)
		TM helix 4	224..240	CDD:320259	5/15 (33%)
		TM helix 5	272..295	CDD:320259	6/22 (27%)
		TM helix 6	320..345	CDD:320259	10/24 (42%)
		TM helix 7	363..388	CDD:320259	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050