Protein Alignment PK2-R2 and NMUR1

DIOPT Version :10

• Sequence 1: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_006047.3
• Gene: NMUR1 / 10316
• HGNCID: 4518
• Length: 426
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 131/384 - (34%)
• Similarity: 197/384 - (51%)
• Gaps: 56/384 - (14%)

  Fly    34 LNISADNLTSLLQGLEPEELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMH 98
            ||::.:.|.....|.:..||.        :.:.||    |.|||:.|.:||.:||:||.|:..|.
Human    40 LNLTDEALRLKYLGPQQTELF--------MPICAT----YLLIFVVGAVGNGLTCLVILRHKAMR 92

  Fly    99 TATNFYLFNLAISDMILLCSGMPQDLYNLWHPDNYPFSDSI--CILESVLSETAANATVLTITAF 161
            |.||:|||:||:||:::|..|:|.:||.:||  ||||...:  |...::|.|....|:||.:||.
Human    93 TPTNYYLFSLAVSDLLVLLVGLPLELYEMWH--NYPFLLGVGGCYFRTLLFEMVCLASVLNVTAL 155

  Fly   162 TVERYIAICHPFRQHTMSKLSRAVKFIFAIWIAALLLALPQAI-----QFSVVMQGM---GTSCT 218
            :||||:|:.||.:..:|...:...:.:.|:|..|:|.:||...     |..|..:|.   ...|.
Human   156 SVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCM 220

  Fly   219 M--KNDFFAHVFAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLL---------QALPRRCYDV-- 270
            :  ....:..|...:..|||..||..:.|||:|||::|:|.|||         .|..|..|..
Human   221 LVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRL 285

  Fly   271 ---NRGISAQTRVIRMLVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQWFNDV---FSILDYTS 329
               :||   :.:|.:||..:.|.|.||||||||.|:|      ..:.|||.:.:   |..:...|
Human   286 QQHDRG---RRQVTKMLFVLVVVFGICWAPFHADRVM------WSVVSQWTDGLHLAFQHVHVIS 341

  Fly   330 GVLYFLSTCINPLLYNIMSHKFREAFKVTLARHFGLGGKNQGRGLPHTYSALRRNQTGS 388
            |:.::|.:..||:||::||.:|||.|:..|.    ||.........|:..:|.|..|||
Human   342 GIFFYLGSAANPVLYSLMSSRFRETFQEALC----LGACCHRLRPRHSSHSLSRMTTGS 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	113/314 (36%)
		TM helix 1	69..94	CDD:320262	11/24 (46%)
		TM helix 2	101..127	CDD:320262	14/25 (56%)
		TM helix 3	140..170	CDD:320262	13/29 (45%)
		TM helix 4	182..204	CDD:320262	6/21 (29%)
		TM helix 5	225..253	CDD:320262	12/27 (44%)
		TM helix 6	275..305	CDD:320262	14/29 (48%)
		TM helix 7	323..348	CDD:320262	7/24 (29%)
NMUR1	NP_006047.3	7tmA_NMU-R1	61..367	CDD:320480	115/320 (36%)
		TM helix 1	61..88	CDD:320480	13/30 (43%)
		TM helix 2	95..121	CDD:320480	14/25 (56%)
		TM helix 3	134..164	CDD:320480	13/29 (45%)
		TM helix 4	176..198	CDD:320480	6/21 (29%)
		TM helix 5	228..257	CDD:320480	12/28 (43%)
		TM helix 6	290..320	CDD:320480	17/38 (45%)
		TM helix 7	335..360	CDD:320480	7/24 (29%)