DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PK2-R2 and nmur1

DIOPT Version :9

Sequence 1:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_002937396.1	Gene:	nmur1 / 100498264	XenbaseID:	XB-GENE-940641	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	401	Identity:	132/401 - (32%)
Similarity:	203/401 - (50%)	Gaps:	72/401 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EELL------PTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLA 109
            ||||      ...|..||:.::      |..||..|.:||.:|||||.::..|.|.||:||.:||
Frog    51 EELLFKYLGPRRSTYFTPICII------YLFIFAVGAVGNTLTCIVIIKHKIMRTPTNYYLLSLA 109

  Fly   110 ISDMILLCSGMPQDLYNLWHPDNYP--FSDSICILESVLSETAANATVLTITAFTVERYIAICHP 172
            |||:::|..|||.:||.||  .|||  |..|.|..:::|.||...|::|.:||.:||||||:.||
Frog   110 ISDLLVLLLGMPLELYELW--SNYPFVFGQSGCSFKTLLFETVCFASILNVTALSVERYIAVVHP 172

  Fly   173 FRQHTMSKLSRAVKFIFAIWIAALLLALPQAIQFSVV---MQGMG-----TSCTMKNDFFAH--V 227
            .|...:...:.|.:.||::|:.::|.::|......::   :.|:|     .:||:....:.:  :
Frog   173 LRAKYVVTRNHAKRVIFSVWVISILCSIPNTSLNGILHLRVLGIGIVPGSATCTVVRPRWIYNLI 237

  Fly   228 FAVSGFLFFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGIS---------AQTRVIRM 283
            ..::...||..||..|.|||:|||::||:.::||.|..:......|..         .:.:|.:|
Frog   238 IQITTIFFFFLPMGTISVLYLLIGLQLKKEKMLQVLETKSGKEGDGYQNVRLQQEKIRRRQVTKM 302

  Fly   284 LVAVAVAFFICWAPFHAQRLMAVYGSTSGIESQW---FNDVFSILDYTSGVLYFLSTCINPLLYN 345
            |..:.|.|.|||||||.:|||..:      .:.|   .:.:||.:...||||::||:.:||:|||
Frog   303 LFILVVVFGICWAPFHTERLMWSF------INDWTEVMHQIFSFVHVISGVLFYLSSVVNPILYN 361

  Fly   346 IMSHKFREAFKVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTMTSMATTTTG 410
            ::|.:|||.||..:...                   |..:.||         |.:..|:...||.
Frog   362 LLSTRFREMFKEVMCHG-------------------RTKRLGS---------RRSSPSVTRVTTR 398

  Fly   411 LNGSANGSGNG 421
            .....|..|||
Frog   399 STVCENVPGNG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	101/284 (36%)
nmur1	XP_002937396.1	7tmA_NMU-R1	67..371	CDD:320480	114/317 (36%)
		TM helix 1	67..94	CDD:320480	13/32 (41%)
		TM helix 2	101..127	CDD:320480	15/25 (60%)
		TM helix 3	140..170	CDD:320480	14/29 (48%)
		TM helix 4	182..204	CDD:320480	6/21 (29%)
		TM helix 5	234..263	CDD:320480	11/28 (39%)
		TM helix 6	294..324	CDD:320480	14/29 (48%)
		TM helix 7	339..364	CDD:320480	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3483
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9540
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060