Protein Alignment CG32473 and AAP1

DIOPT Version :10

• Sequence 1: NP_731787.1
• Gene: CG32473 / 41636
• FlyBaseID: FBgn0052473
• Length: 1025
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 889
• Identity: 269/889 - (30%)
• Similarity: 471/889 - (52%)
• Gaps: 58/889 - (6%)

  Fly   144 LPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLE-PIAFIPVHVKQLN--------VSTVEVKR 199
            ||..:.|..|.:.|.|:.....:.|::.|.||:.: .|..:.::..:::        |:.:||.:
Yeast     6 LPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNK 70

  Fly   200 LDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFTGSLVDRITGMYQSSYLDKL 263
            .:...      ..||.|.:..||          ..| :..|.:.|:|.|.|::.|.|::.|.||:
Yeast    71 NENQQ------KATLVFPNGTFE----------NLGPSAKLEIIFSGILNDQMAGFYRAKYTDKV 119

  Fly   264 KNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITEV 328
            ...::.:.:|:.|.|.||:||||||||.|||.|.:|:...|...:  ||||.|.:|.:.......
Yeast   120 TGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTH--LSNMDVRNETIKEGKKYT 182

  Fly   329 TFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFN 393
            ||..|..|||||.||:|:|.:|.|:  ....|.::||:.|...:..|:|.:.||..:.::.:.||
Yeast   183 TFNTTPKMSTYLVAFIVADLRYVES--NNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFN 245

  Fly   394 VSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNL 458
            :.|.|||:|:||:.:|.:||||||||||:|...||.|...||....||||.|:.|||||||||||
Yeast   246 IEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNL 310

  Fly   459 VTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPA 523
            |||:||..||||||||:::.:....:..|||.:..|:|.:.|...|.:|:..:||||...:.:..
Yeast   311 VTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNAD 375

  Fly   524 EITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDV 588
            ||.:.||.|:||||::|:||:...:|||......::||.:..|..|.|.|...|:.:..|.  ||
Yeast   376 EINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK--DV 438

  Fly   589 KQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSE 653
            ..:|..||:::|.||:.|::..:...|||.|:|:..|   .:.|..:..|...:.:..::.|::
Yeast   439 CSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGD---VKEEEDTTIYPILLALKDSTGIDN- 499

  Fly   654 VQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHL 718
              :|:.  |:..||..|..| .:.|||.:|.|.:..:|..|:||:    |.......|..||..|
Yeast   500 --TLVL--NEKSATFELKNE-EFFKINGDQSGIFITSYSDERWAK----LSKQANLLSVEDRVGL 555

  Fly   719 LNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYY--TDLYTNYTTYARK 781
            :.||..|:|:|..:.:..|:|||..::|..:|.|....::|:.|::...:  .|:......:...
Yeast   556 VADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLD 620

  Fly   782 LLTPIVEKVTFTVAAD--HLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRD 844
            |:...:.::.:.:..|  ....||::.:.|:||:.|:|.....||.:|.:: |:...:..|.:..
Yeast   621 LVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEY-ANGNKQAIPALFK 684

  Fly   845 VVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQD 909
            .|.:..:.::..|..:::::.:|.:...::||:..:..|...:...||:|.:::..| ..|..||
Yeast   685 AVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLD-GTVLNQD 748

  Fly   910 YFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFA 974
            ::..:..|..:..|...:|.:::|:|:::..|.......||.::......|::...||::..|::
Yeast   749 FYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYS 813

  Fly   975 KYPEAGAG-TAARQQALEAVKANIKWLAANKAQVGEWLANYVQQ 1017
            :....|.. |.|  |||:.:::..:|::.::    |.:|.|:::
Yeast   814 RKVTKGFDQTLA--QALDTIRSKAQWVSRDR----EIVATYLRE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	M1_APN-Q_like	151..597	CDD:341064	168/455 (37%)
		ERAP1_C	676..995	CDD:463368	74/323 (23%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	168/455 (37%)
		ERAP1_C	517..833	CDD:463368	74/323 (23%)