DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and AAP1

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	889	Identity:	269/889 - (30%)
Similarity:	471/889 - (52%)	Gaps:	58/889 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLE-PIAFIPVHVKQLN--------VSTVEVKR 199
            ||..:.|..|.:.|.|:.....:.|::.|.||:.: .|..:.::..:::        |:.:||.:
Yeast     6 LPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNK 70

  Fly   200 LDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFTGSLVDRITGMYQSSYLDKL 263
            .:...      ..||.|.:..||          ..| :..|.:.|:|.|.|::.|.|::.|.||:
Yeast    71 NENQQ------KATLVFPNGTFE----------NLGPSAKLEIIFSGILNDQMAGFYRAKYTDKV 119

  Fly   264 KNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITEV 328
            ...::.:.:|:.|.|.||:||||||||.|||.|.:|:...|...:  ||||.|.:|.:.......
Yeast   120 TGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTH--LSNMDVRNETIKEGKKYT 182

  Fly   329 TFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFN 393
            ||..|..|||||.||:|:|.:|.|:  ....|.::||:.|...:..|:|.:.||..:.::.:.||
Yeast   183 TFNTTPKMSTYLVAFIVADLRYVES--NNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFN 245

  Fly   394 VSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNL 458
            :.|.|||:|:||:.:|.:||||||||||:|...||.|...||....||||.|:.|||||||||||
Yeast   246 IEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNL 310

  Fly   459 VTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPA 523
            |||:||..||||||||:::.:....:..|||.:..|:|.:.|...|.:|:..:||||...:.:..
Yeast   311 VTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNAD 375

  Fly   524 EITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDV 588
            ||.:.||.|:||||::|:||:...:|||......::||.:..|..|.|.|...|:.:..|.  ||
Yeast   376 EINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK--DV 438

  Fly   589 KQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSE 653
            ..:|..||:::|.||:.|::..:...|||.|:|:..|   .:.|..:..|...:.:..::.|::
Yeast   439 CSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGD---VKEEEDTTIYPILLALKDSTGIDN- 499

  Fly   654 VQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHL 718
              :|:.  |:..||..|..| .:.|||.:|.|.:..:|..|:||:    |.......|..||..|
Yeast   500 --TLVL--NEKSATFELKNE-EFFKINGDQSGIFITSYSDERWAK----LSKQANLLSVEDRVGL 555

  Fly   719 LNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYY--TDLYTNYTTYARK 781
            :.||..|:|:|..:.:..|:|||..::|..:|.|....::|:.|::...:  .|:......:...
Yeast   556 VADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLD 620

  Fly   782 LLTPIVEKVTFTVAAD--HLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRD 844
            |:...:.::.:.:..|  ....||::.:.|:||:.|:|.....||.:|.:: |:...:..|.:..
Yeast   621 LVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEY-ANGNKQAIPALFK 684

  Fly   845 VVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQD 909
            .|.:..:.::..|..:::::.:|.:...::||:..:..|...:...||:|.:::..| ..|..||
Yeast   685 AVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLD-GTVLNQD 748

  Fly   910 YFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFA 974
            ::..:..|..:..|...:|.:::|:|:::..|.......||.::......|::...||::..|::
Yeast   749 FYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYS 813

  Fly   975 KYPEAGAG-TAARQQALEAVKANIKWLAANKAQVGEWLANYVQQ 1017
            :....|.. |.|  |||:.:::..:|::.::    |.:|.|:::
Yeast   814 RKVTKGFDQTLA--QALDTIRSKAQWVSRDR----EIVATYLRE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	151/402 (38%)
		M1_APN_2	151..602	CDD:189008	170/460 (37%)
		ERAP1_C	677..992	CDD:288671	74/319 (23%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	266/880 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I1338
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	6	5.910