DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and TMA108

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	1015	Identity:	218/1015 - (21%)
Similarity:	407/1015 - (40%)	Gaps:	221/1015 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LPKQIKPSKY--RLHLRPDLERKNYSGNISISLQ----------VLEPIAFIPVHVKQLNV---- 192
            |...:.||.|  ||.:.|.....|:.|:..|.|:          :.:......:|.|.|.|
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH 72

  Fly   193 STV-----EVKRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAGN---YSLLLNFTGSL-- 247
            :|:     ::|...::|..|.                :...|.|::..|   ..|.:.:.|.:
Yeast    73 ATIGSTKFDLKISQDTGKHLS----------------IFNSESPIQLSNDCPLILSVQYVGKIRD 121

  Fly   248 ----VDRITGMYQSSYLD-KLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDE 307
                .|:..|:::::::| |....:..:::|..:|..|...|||.|||:.|:.|.:.:|..:  :
Yeast   122 IKTHHDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDA--Q 184

  Fly   308 YHVLSNMPVASEYVDG-DITE---VTFAETVPMSTYLAAFVVSDFQYKETTV--EG-TSIALKVY 365
            |..:||.||  |.|:. |.::   |.||:|..|:|.:..|.:.|.::.:|.:  || .:|.:.:|
Yeast   185 YKAVSNTPV--EMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIY 247

  Fly   366 APPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYD 430
            | |..:....:.|||....:....:||...|.|||||.|.:|.....||||:|::|.:...||..
Yeast   248 A-PWDIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIP 311

  Fly   431 ES--TSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQ---MHPEWD 490
            .:  .:.:|.:|...::| |||.|||.||.::.:.|..||.||.||::|....::|   :...|.
Yeast   312 PNALANETVREQAQQLIV-HELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWT 375

  Fly   491 MDNQFVIEELHPVLTIDATLASHPIVKSIES-----PAEITEYFDTITYSKGAALVRMLENLVGE 550
            .: .::::::.|.:..||...:...:..|..     .::.::.||...|:||..::|.|:...||
Yeast   376 SE-PYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGE 439

  Fly   551 EKLRNA-------TTRYLVR---------HIYSTATTEDYLTAVEEEEGLEFDVKQIMQTWTEQM 599
            ..|:..       |..:..|         ||.....::              ::...:.:||...
Yeast   440 SHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQ--------------NITNFVSSWTRTP 490

  Fly   600 GLPVVEV---EKSGSTY-KLTQKRFLANEDDYAAEAEASSFNYRWSIPI-TYTSSINSEVQSLIF 659
            |||||:|   ||.|.|. ||||.||:   :..:.|.:....:..:.:|: ........:.::::.
Yeast   491 GLPVVKVEVEEKDGKTQTKLTQHRFI---NQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLL 552

  Fly   660 NHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANT 724
            ...      ||..:...:.||....|||||:|.||:...||:. |.:.||.|..|...:..|.:.
Yeast   553 TDR------TLKFDYPILVINHLAQGYYRVSYESEECYALIND-KITEETLSEIDLRKIFLDLSQ 610

  Fly   725 LAAAGQLNYSVAL----DLISYLESEQDYV------PWSVGTSALATLRNRVYYTDLYTNYTTYA 779
            .........|:.|    .:::::.|....:      |.|.|...|.|:......:....::  ..
Yeast   611 FIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSF--LK 673

  Fly   780 RKLLTPIVEKVTFTVAA-DHLENRLRIKVLSSACSLGHESS--LQQAVTLFNQWLASPETRPNPD 841
            :|::.|:..|:.:.... |...|...:||:|....|...|:  .:.....|...|..|.:....:
Yeast   674 KKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLE 738

  Fly   842 IRDVVYYYGLQQVNTEAAWDQVWKL---------------YLDESDAQEKLKLMN--------CL 883
            :.:.:.....|.......|.:::.|               ..|::.::..:.:.|        ||
Yeast   739 LVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCL 803

  Fly   884 TAVQVPWLLQRYINWAWDESNVRRQDY-FTLLGY-------ISTN-----PVGQSLVWDYVREN- 934
            .:.    ::::.:|:.  .||:..:.. ..|.|:       ::.|     .|.:..:|::...|
Yeast   804 DSD----IVKKTLNFI--TSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNF 862

  Fly   935 --WEKLVDRFGINE--------RTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQA 989
              |.:...|.|...        |::..:|               .|.|.|..|          |.
Yeast   863 DQWARKATRKGTTTGDHLHKALRSISLII---------------FQMFVADEP----------QK 902

  Fly   990 LEAVKANIKWLAANKAQVGEWLANY------VQQSSVTNR 1023
            :|      |::...|.::|:.|.:.      |||...:.:
Yeast   903 IE------KFINLEKEKLGQSLLSLDDIWASVQQDEESRK 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	112/440 (25%)
		M1_APN_2	151..602	CDD:189008	124/514 (24%)
		ERAP1_C	677..992	CDD:288671	65/374 (17%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	218/1015 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910