DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and APE2

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	891	Identity:	289/891 - (32%)
Similarity:	479/891 - (53%)	Gaps:	69/891 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPLK 208
            ||..:.|..|.|.:.||.:...:.|::.|.|::..|.      :..:.::||:.   |...|.:.
Yeast   102 LPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPA------IDTVTLNTVDT---DIHSAKIG 157

  Fly   209 DITPTLTFAHPEFEYWVTEFEQPLEA-----GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSR 268
            |:|.:...:  |.|..||.|..|...     ||..|.:.|||.|.|.:.|.|::.|.|||...::
Yeast   158 DVTSSEIIS--EEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETK 220

  Fly   269 SIISTKFEPTYARQAFPCFDEPALKAQFTIT-VARPSGDEYHVLSNMPVASEYV-DGDITEVTFA 331
            .:.:|:.|||.||:||||||||.|||.|.|| |:.||...   ||||.|.:||| ||  .:||..
Yeast   221 YMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTH---LSNMDVKNEYVKDG--KKVTLF 280

  Fly   332 ETVP-MSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVS 395
            .|.| |||||.||:|::.:|.|:  :...|.::|||.|...:..|:|.|..|..:|::...|.:.
Yeast   281 NTTPKMSTYLVAFIVAELKYVES--KNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQ 343

  Fly   396 YALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVT 460
            |.|||:|.||:.:|.:||||||||||:|...||.|:..|:....||||.||.|||||||||||||
Yeast   344 YPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVT 408

  Fly   461 MNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEI 525
            |:||..||||||||:::.:....:..|||.:..|:|.:.|...|::|:..:||||...::...||
Yeast   409 MDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEI 473

  Fly   526 TEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQ 590
            .:.||.|:|||||:|:||:...:|||......::||.:..|..|.|||...|:.:..|.  ||:.
Yeast   474 NQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGK--DVRS 536

  Fly   591 IMQTWTEQMGLPVVEVEKSGSTYKLT--QKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSE 653
            :|..||:::|.||:.|.:.|:. |:|  |.|:|:..|   .:.:.....|...:.:...:.::|.
Yeast   537 VMNIWTKKVGFPVISVSEDGNG-KITFRQNRYLSTAD---VKPDEDKTIYPVFLALKTKNGVDSS 597

  Fly   654 VQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHL 718
            |..     ::...||.| |:.::.|:|:.|.|.|..:|..|:||:    |....:..|..||..|
Yeast   598 VVL-----SERSKTIEL-EDPTFFKVNSEQSGIYITSYTDERWAK----LGQQADLLSVEDRVGL 652

  Fly   719 LNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYY-----TDLYTNYTTY 778
            :.|..||:|:|..:.:..|:|:|...:|:.:|.|....::::::::...:     .|...|:|
Yeast   653 VADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFT-- 715

  Fly   779 ARKLLTPIVEKV--TFTVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPD 841
             ::|::.:...:  .|..:......||::.:..:||:.......:.|:.:|..:.:..:......
Yeast   716 -KQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPAL 779

  Fly   842 IRDVVYYYGLQQVNTEAA------WDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAW 900
            |:.:|:       ||.|.      :::|:|:|||.....|||..:..|...:.|.||:|.:.:.:
Yeast   780 IKPIVF-------NTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLF 837

  Fly   901 DESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETK 965
            | ..|..||.:..:..:..:..|...:|::|::||::||.|.......||.::...|:.|::..|
Yeast   838 D-GTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQK 901

  Fly   966 LEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            ::|:::|||.....|...:. .|:|:.:.:..:|:..::..|.::|
Yeast   902 IDEIKKFFATKSTKGFDQSL-AQSLDTITSKAQWVNRDRDVVNKYL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	167/400 (42%)
		M1_APN_2	151..602	CDD:189008	188/458 (41%)
		ERAP1_C	677..992	CDD:288671	78/327 (24%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	287/884 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I1338
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	6	5.910