DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Anpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_112274.1	Gene:	Anpep / 81641	RGDID:	2991	Length:	965	Species:	Rattus norvegicus

Alignment Length:	976	Identity:	323/976 - (33%)
Similarity:	523/976 - (53%)	Gaps:	91/976 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 LLSTKPIISVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLG---------FRLPKQIK 149
            ||....:.::::.:..|..:...:.::|.:|...|...:|:....|..         :||||.:.
  Rat    17 LLGVAAVCTIIALSVVYAQEKNRNAENSAIAPTLPGSTSATTSTTNPAIDESKPWNQYRLPKTLI 81

  Fly   150 PSKYRLHLRPDLERKN-----YSGNISISLQVLEPIAFIPVHVKQLNVST-----VEVKRLDESG 204
            |..|::.|||.|....     :.|:.::.....|....|.:|.|:||.:.     |.::.|.::.
  Rat    82 PDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKGNHRVALRALGDTP 146

  Fly   205 APLKDITPTLTFAHPEFEYWVTEFEQPLEAGN-YSLLLNFTGSLVDRITGMYQSSYLDKLKNRSR 268
            ||..|.|..:    ...||.|...:..|..|: |.:...|.|.|.|.:.|.|:|.|::  ....:
  Rat   147 APNIDTTELV----ERTEYLVVHLQGSLVKGHQYEMDSEFQGELADDLAGFYRSEYME--GGNKK 205

  Fly   269 SIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNM-PVASEYVDGD----ITEV 328
            .:.:|:.:...||::||||||||:||.|.||:..|  :....|||| |..|..:..|    :||
  Rat   206 VVATTQMQAADARKSFPCFDEPAMKASFNITLIHP--NNLTALSNMLPKDSRTLQEDPSWNVTE- 267

  Fly   329 TFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEK--TQYALDTAAGVMAYYINY 391
             |..|..|||||.|::||:|:|.| .|....:.::::|.|:.:::  ..|||.....::.::..:
  Rat   268 -FHPTPKMSTYLLAYIVSEFKYVE-AVSPNRVQIRIWARPSAIDEGHGDYALQVTGPILNFFAQH 330

  Fly   392 FNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFG 456
            :|.:|.|.|.|.:|:|||.:||||||||||:||:||::|..:||..||:||..|:||||||||||
  Rat   331 YNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSSSISNKERVVTVIAHELAHQWFG 395

  Fly   457 NLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI---VKS 518
            ||||::|||||||||||||::|:.|.....|.|::.:..|:.:::.|:.:||..:|||:   ...
  Rat   396 NLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLNDVYRVMAVDALASSHPLSSPANE 460

  Fly   519 IESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATT------EDYLTA 577
            :.:||:|:|.||:|||||||:::|||.:.:.|:..:...:.||  |.:..:.|      |....|
  Rat   461 VNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYL--HTFQYSNTIYLDLWEHLQQA 523

  Fly   578 VEEEEGLEF--DVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRW 640
            |:.:..::.  .|..||..|..|||.||:.|  :.||.::.|:.||.  |..:.....|.|||.|
  Rat   524 VDSQTAIKLPASVSTIMDRWILQMGFPVITV--NTSTGEIYQEHFLL--DPTSKPTRPSDFNYLW 584

  Fly   641 SIPITYTSS-------INSEV-QSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWA 697
            .:||.|..:       :.:|. ||..|..:.||          |:.:|.|..|||:|||....|.
  Rat   585 IVPIPYLKNGKEDHYWLETEKNQSAEFQTSSNE----------WLLLNINVTGYYQVNYDENNWR 639

  Fly   698 ELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATL 762
            ::.:.|:.........:||.:::|:..||:||:|:.::.|....:|.||.:|:||....|:|...
  Rat   640 KIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYMPWEAALSSLNYF 704

  Fly   763 RNRVYYTDLYTNYTTYARKLLTPIVEKVTFTVAADH--------LENRLRIKVLSSACSLGHESS 819
            :.....:::|.....|.:|.:||:.  ..|.:..::        :|....|..:|:|||.|.|..
  Rat   705 KLMFDRSEVYGPMKRYLKKQVTPLF--AYFKIKTNNWLDRPPTLMEQYNEINAISTACSSGLEEC 767

  Fly   820 LQQAVTLFNQWLASPETRP-NPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCL 883
            ....|.|::||:.:.:..| :|::|..||...: ....|..|:..|:.:...:...|..||.:.|
  Rat   768 RDLVVGLYSQWMNNSDNNPIHPNLRSTVYCNAI-AFGGEEEWNFAWEQFRKATLVNEADKLRSAL 831

  Fly   884 TAVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERT 948
            ......|:|.||:::..:...:|:||..:.:..|:.|.|||:||||:||.||:||.:.:|....:
  Rat   832 ACSNEVWILNRYLSYTLNPDYIRKQDATSTIVSIANNVVGQTLVWDFVRSNWKKLFEDYGGGSFS 896

  Fly   949 LGRLIPTITARFSTETKLEEMQQFFAKYPEA----GAGTAARQQALEAVKANIKWLAANKAQVGE 1009
            ...||..:|.|||:|.:|::::||  |...:    |:||.|.:||||..||||||:..||..|.:
  Rat   897 FANLIQGVTRRFSSEFELQQLEQF--KEDNSATGFGSGTRALEQALEKTKANIKWVKENKDVVLK 959

  Fly  1010 W 1010
            |
  Rat   960 W 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	161/414 (39%)
		M1_APN_2	151..602	CDD:189008	177/479 (37%)
		ERAP1_C	677..992	CDD:288671	98/327 (30%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68		5/23 (22%)
		Metalloprotease	69..965		315/924 (34%)
		Peptidase_M1	75..479	CDD:279741	161/414 (39%)
		M1_APN_2	84..550	CDD:189008	177/478 (37%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	619..942	CDD:288671	98/327 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820